• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dermatology Online Journal >Cutaneous HIV-associated Kaposi sarcoma: a potential setting for management by clinical observation
【24h】

Cutaneous HIV-associated Kaposi sarcoma: a potential setting for management by clinical observation

机译：皮肤性的艾滋病毒相关的卡波济肉瘤：通过临床观察进行管理的潜在环境

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Kaposi sarcoma (KS) is a malignancy of viral etiology whose course ranges from cutaneous limited lesions to fulminant disease with multi-organ involvement. Four clinical variants of the disease exist: classic, endemic, iatrogenic, and epidemic. Iatrogenic and epidemic variants of Kaposi sarcoma develop in the setting of immune suppression. Transplant recipients who develop iatrogenic KS typically demonstrate improvement of lesions following de-escalation of immunosuppressive therapy. Similarly, HIV-infected patients who begin highly active antiretroviral therapy (HAART) experience immune reconstitution, which can induce KS regression. We describe two patients with varying clinical outcomes of cutaneous-limited HIV-associated KS after immune reconstitution with HAART. We propose that immune reconstitution with HAART, followed by clinical and radiographic surveillance for disease progression, may be an appropriate initial management strategy for limited cutaneous HIV-associated KS. In patients with more extensive disease at presentation or failure of HAART alone, antineoplastic therapy should be instituted.
机译：卡波济肉瘤（KS）是一种病毒性病因，其病程范围从皮肤有限的病变到多器官受累的暴发性疾病。该疾病有四种临床变体：经典，地方性，医源性和流行病。卡波西肉瘤的医源性和流行病变体在免疫抑制方面发展。发生医源性KS的移植受者通常会在免疫抑制治疗逐步降低后表现出病变的改善。同样，开始高度活跃的抗逆转录病毒疗法（HAART）的HIV感染患者会经历免疫重建，这会导致KS消退。我们描述了两名患者在用HAART免疫重建后，皮肤受限的HIV相关KS的临床结局有所不同。我们建议用HAART进行免疫重建，然后进行临床和放射学监测疾病进展，可能是有限的皮肤HIV相关KS的合适初始治疗策略。对于仅表现为HAART或HAART失败的更广泛疾病的患者，应开始抗肿瘤治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号