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首页> 外文期刊>Dermato-Endocrinology >The effect on acne quality of life of topical azelaic acid 15% gel versus a combined oral contraceptive in adult female acne: A randomized trial
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The effect on acne quality of life of topical azelaic acid 15% gel versus a combined oral contraceptive in adult female acne: A randomized trial

机译：15％壬二酸局部凝胶与联合口服避孕药对成年女性痤疮对痤疮生活质量的影响：一项随机试验

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Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and have show some clinical differences compared to adolescent acne. In addition to the physical aspects, acne has a strong psychosocial impact and can lead to the onset of signs and symptoms of depression, such as anger. Our objective was to evaluate the effect on acne-specific quality of life in adult women treated with topical azelaic acid versus a combined oral contraceptive. The study population consisted of 38 adult women with acne and without any features of hyperandrogenism recruited from the clinic of Dermatology Hospital Division of S?o Paulo, Federal University of S?o Paulo from January 2012 to September 2014. Patients were randomized into two different groups: one receiving containing 20 ug of ethinylestradiol and 3 mg drospirenone in a regimen of 24?days of medication, a combined oral contraceptive (COC), and the other group topical 15% azelaic acid (AA) gel, twice daily, both for six months. The quality of life was evaluated at baseline and end of treatment with an acne specific measure (Acne-QoL). Before treatment, our data revealed a significant impact of the presence of acne on quality of life. Both treatments resulted in improvement with significant statistical values in quality of life scores. Comparing the four domains of Acne-QoL, patients treated with an oral contraceptive showed greater improvement in two domains (self-perception and acne symptoms) than those treated with azelaic acid.
机译：寻常痤疮是一种慢性炎症性疾病，会影响皮脂腺单元。最近的研究表明，成年女性中痤疮的病例越来越多。这些病例主要是正常雄激素，并且与青春期痤疮相比显示出一些临床差异。除身体方面外，痤疮还具有强烈的社会心理影响，并可能导致抑郁症的症状和体征发作，例如愤怒。我们的目标是评估用局部壬二酸和联合口服避孕药治疗的成年女性对痤疮特异性生活质量的影响。研究人群由2012年1月至2014年9月从圣保罗联邦大学圣保罗皮肤病医院诊所招募的38名成年女性痤疮和无高雄激素血症的成年女性组成。患者被随机分为两个各组：一组在治疗24天的疗程中接受含有20 ug的炔雌醇和3 mg屈螺酮，组合口服避孕药（COC），另一组每天两次局部用15％壬二酸（AA）凝胶，均用于六个月。在治疗的基线和治疗结束时用痤疮特异性措施（Acne-QoL）评估生活质量。治疗前，我们的数据显示痤疮的存在对生活质量有重大影响。两种治疗均改善了生活质量，并具有显着的统计学价值。比较痤疮-生活质量的四个方面，口服避孕药治疗的患者比壬二酸治疗的患者在两个方面（自我知觉和痤疮症状）的改善更大。

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