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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >The effects of B vitamins on pain relief and improving physical function in patients with medial compartment knee osteoarthritis
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The effects of B vitamins on pain relief and improving physical function in patients with medial compartment knee osteoarthritis

机译：B族维生素对内侧间隔膝关节骨关节炎患者缓解疼痛和改善身体机能的影响

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摘要

The anti-inflammatory and analgesic effects of B vitamins have been already demonstrated. It seems that these agents are effective in treating knee osteoarthritis (KOA), which is associated with an inflammatory status of the joint. However, the available documents showing the efficacy of these vitamins are so limited. In the current study, we investigated the effects of B vitamins on pain relief and function improvement in patients with KOA. Sixty patients with mild to moderate KOA were randomly divided into two equal groups of celecoxib (control) and celecoxib with B vitamins (neurobion). Patients were treated for two months. Before and after the treatment, patients' pain intensity and function were measured using visual analogue scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) respectively. On the last visit, the pain intensity significantly decreased and WOMAC scores significantly increased in both groups, respectively (p0.001). However, the WOMAC scores were the same in both groups , while the pain intensity was significantly lower in neurobion group on the last visit (p0.001). Our findings showed that prescribing B vitamins can effectively exacerbate the analgesic effect of celecoxib in patients with KOA without any complications.
机译：维生素B的抗炎和镇痛作用已经得到证明。看来这些药物可有效治疗与关节的炎症有关的膝骨关节炎（KOA）。但是，显示这些维生素功效的现有文献非常有限。在当前的研究中，我们调查了维生素B对KOA患者的疼痛缓解和功能改善的影响。将60例轻度至中度KOA患者随机分为两组，两组分别为塞来昔布（对照组）和含B维生素的塞来昔布（神经调节剂）。患者接受了两个月的治疗。治疗前后，分别使用视觉模拟量表（VAS）和西安大略省和麦克马斯特大学关节炎指数（WOMAC）测量患者的疼痛强度和功能。在最后一次就诊时，两组的疼痛强度均显着降低，WOMAC评分均显着提高（p <0.001）。但是，两组的WOMAC评分均相同，而在最后一次访视时神经元组的疼痛强度明显较低（p <0.001）。我们的研究结果表明，处方B族维生素可以有效地增强塞来昔布对KOA患者的镇痛作用，而不会引起任何并发症。

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