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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Spectrophotometric estimation of paracetamol and promethazine in tablet dosage forms
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Spectrophotometric estimation of paracetamol and promethazine in tablet dosage forms

机译：分光光度法测定片剂中对乙酰氨基酚和异丙嗪的含量

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Two cost effective spectrophotometric methods are developed and validated for quantitative determination of paracetamol (PCT) and promethazine hydrochloride (PMZ) in tablet dosage form. Method I is based on the simultaneous equation and Method II on the absorbance ratio.The absorption maxima were found to be at 244 nm and 254 nm in distilled water for both the drugs. Beer's law is obeyed in the concentration range of 5-25 μg/ml for paracetamol and promethazine hydrochloride with correlation coefficient within range of 0.996 - 0.998. The simultaneous equation method is based on the additivity of absorbencies and the absorbance ratio method involves determination of the ratio of absorbance at 254 nm, the absorption maxima of promethazine and isoabsorptive wavelength 248 nm. The accuracy was assessed by recovery studies.
机译：开发并验证了两种成本有效的分光光度法，用于定量测定片剂剂型中对乙酰氨基酚（PCT）和盐酸异丙嗪（PMZ）。方法I基于联立方程，方法II基于吸光度比，两种药物在蒸馏水中的最大吸收分别为244 nm和254 nm。扑热息痛和盐酸异丙嗪的浓度范围为5-25μg/ ml，符合比尔定律，相关系数在0.996-0.998范围内。联立方程法是基于吸光度的加和法，吸光度比法涉及确定254 nm处的吸光度比，异丙嗪的最大吸收度和等吸收波长248 nm。通过恢复研究评估准确性。

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