A facile synthesis of 1-(4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)-5-methyl-3-aryl-1,3,5-triazinane-2-thiones and 3-(4-(1H-imidazo[4,5-b]pyridine-2-yl)phenyl)-5-aryl-1,3,5-oxadiazinane-4-thiones

Ajay Kumar R; Dayakar G; I. Sujatha; Kusuma B.

首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >A facile synthesis of 1-(4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)-5-methyl-3-aryl-1,3,5-triazinane-2-thiones and 3-(4-(1H-imidazo[4,5-b]pyridine-2-yl)phenyl)-5-aryl-1,3,5-oxadiazinane-4-thiones

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A facile synthesis of 1-(4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)-5-methyl-3-aryl-1,3,5-triazinane-2-thiones and 3-(4-(1H-imidazo[4,5-b]pyridine-2-yl)phenyl)-5-aryl-1,3,5-oxadiazinane-4-thiones

机译：轻松合成1-（4-（1H-咪唑并[4,5-b]吡啶-2-基）苯基）-5-甲基-3-芳基-1,3,5-三嗪烷-2-硫酮和3 -（4-（1H-咪唑并[4,5-b]吡啶-2-基）苯基）-5-芳基-1,3,5-恶二嗪烷-4-硫酮

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4-(1H-imidazo[4,5-b]pyridin-2-yl)benzenamine (1) reacts with aromatic isothiocyanates to form compound 2 which is cyclized to 1-(4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)-5-methyl-3-aryl-1,3,5-triazinane-2-thiones (3a-h) and 3- (4-(1H-imidazo[4,5-b]pyridine-2-yl)phenyl)-5-aryl-1,3,5-oxadiazinane-4-thiones (4a-h). All the compounds are analysed by 1H NMR and Mass spectra.

机译：4-（1H-咪唑并[4,5-b]吡啶-2-基）苯胺（1）与芳族异硫氰酸酯反应形成化合物2，将其环化为1-（4-（1H-咪唑并[4,5-b] ] pyridin-2-yl）phenyl）-5-methyl-3-aryl-1,3,5-triazinane-2-thiones（3a-h）and 3-（4-（1H-imidazo [4,5-b ]吡啶-2-基）苯基）-5-芳基-1,3,5-恶二嗪烷-4-硫酮（4a-h）。所有化合物均通过1 H NMR和质谱分析。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2014年第5期|共4页
作者
Ajay Kumar R; Dayakar G; I. Sujatha; Kusuma B.;
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A facile synthesis of 1-(4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)-5-methyl-3-aryl-1,3,5-triazinane-2-thiones and 3-(4-(1H-imidazo[4,5-b]pyridine-2-yl)phenyl)-5-aryl-1,3,5-oxadiazinane-4-thiones

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