• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Pharmacological examination and synthesis of some schiff bases and thiazolidinone derivatives of 5-amino-1H-imidazole- -carboxamide
【24h】

Pharmacological examination and synthesis of some schiff bases and thiazolidinone derivatives of 5-amino-1H-imidazole- -carboxamide

机译：5-氨基-1H-咪唑-羧酰胺的一些席夫碱和噻唑烷酮衍生物的药理学检查和合成

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Schiff bases and thiazolidinone derivatives of 5-amino-1H-imidazole -4-carboxamide have been prepared and tested for pharmacological activities. Schiff base derivatives have been obtained by reacting 5-amino-1H-imidazole -4- carboxamide with suitable aromatic aldehyde which were further converted to thiazolidinone derivatives by reaction of Schiff bases with mercaptoacetic acid. The structure of synthesized compounds have been established on the basis of their spectral (IR, 1H NMR and mass) data. The purity of the synthesized compounds was confirmed by TLC. Good level of pharmacological activity has been displayed by both categories of compounds against tested pathogenic microorganism. Thiazolidinone derivatives (2a-f) showed higher activity than schiff base derivatives (1a-f).
机译：已经制备了5-氨基-1H-咪唑-4-羧酰胺的席夫碱和噻唑烷酮衍生物，并对其药理活性进行了测试。通过使5-氨基-1H-咪唑-4-羧酰胺与合适的芳族醛反应获得席夫碱衍生物，席夫碱与巯基乙酸反应进一步将其转化为噻唑烷酮衍生物。合成化合物的结构已根据其光谱（IR，1H NMR和质量）数据确定。通过TLC确认合成的化合物的纯度。这两类化合物对被测病原微生物均显示出良好的药理活性水平。噻唑烷酮衍生物（2a-f）比席夫碱衍生物（1a-f）具有更高的活性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号