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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Antimicrobial, free radical scavenging activities and chemical composition of Peltophorum pterocarpum Baker ex K. Heyne stem extract
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Antimicrobial, free radical scavenging activities and chemical composition of Peltophorum pterocarpum Baker ex K. Heyne stem extract

机译：百日咳贝克氏菌提取物的抗菌，自由基清除活性和化学成分

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Stem infusion of Peltophorum pterocarpum Baker ex K. Heyne used in dysentery, for gargles, tooth powder and muscular pain. In present paper antimicrobial, antioxidant along with their phytochemical evaluation will be performed. Pet. ether, dichloromethane, ethyl acetate and methanol fractions were tested for their antimicrobial (using agar well diffusion method) and antioxidant activities (DPPH and FARP methods). Bioactive fraction was further subjected to GC-MS analysis for evaluation of its chemical composition. Maximum antimicrobial inhibition was demonstrated by ethyl acetate extract against Bacillus subtilis, Pseudomonas aeruginosa and Satphylococcus aureus (IZ 17.33 ± 0.33, 17.00 ± 0.00, with MIC of 31.25 and 125 μg/mL respectively). In antioxidant potentials, similar fraction showed significant activity i.e. 6 μg/mL with IC50 value of 96.70 ± 0.22 at 80 μg/mL concentrations, coinciding with FRAP results (1310.00 ± 0.00 mg AAE/g dw antioxidant potentials). Based on the results, ethyl acetate bioactive fraction was further subjected to GC-MS studies where 58 distinct peaks were observed. Valeranone (RT: 13.67 of Total: 28.00 %) identified as the major peak with β-sitosterol (area 5.51%), isosativene (RT: 10.70, area 2.77%), hexadecanoic acid (area 3.71%) and octadecanoic acid (area 2.39%).
机译：贝克勒海因贝克公司的Peltophorum pterocarpum Baker的茎浸液用于痢疾，用于漱口，牙粉和肌肉疼痛。在本文中，将进行抗微生物剂，抗氧化剂及其植物化学评估。宠物。测试了乙醚，二氯甲烷，乙酸乙酯和甲醇馏分的抗菌（采用琼脂井扩散法）和抗氧化活性（DPPH和FARP方法）。将生物活性级分进一步进行GC-MS分析以评估其化学组成。乙酸乙酯提取物对枯草芽孢杆菌，铜绿假单胞菌和金黄色葡萄球菌的抑制作用最大（IZ为17.33±0.33、17.00±0.00，MIC分别为31.25和125μg/ mL）。在抗氧化剂潜力中，相似的馏分显示出显着的活性，即6μg/ mL，在80μg/ mL浓度下的IC50值为96.70±0.22，与FRAP结果一致（1310.00±0.00 mg AAE / g dw抗氧化剂潜力）。根据结果​​，将乙酸乙酯生物活性级分进一步进行GC-MS研究，观察到58个不同的峰。缬草酮（RT：总计13.67％：28.00％）被确定为主要峰，其中β-谷固醇（面积5.51％），异黄酮（RT：10.70，面积2.77％），十六烷酸（面积3.71％）和十八烷酸（面积2.39） ％）。

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