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首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Quantitative analysis of serum dipeptidyl peptidase IV enzyme in oral squamous cell carcinoma
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Quantitative analysis of serum dipeptidyl peptidase IV enzyme in oral squamous cell carcinoma

机译：口腔鳞癌中血清二肽基肽酶IV酶的定量分析

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Dipeptidyl Peptidase IV (DPP IV) is an enzyme which splits N-terminal X-proline from peptides. The objective of this study was to present a reliable test to quantitatively estimate the serum Dipeptidyl Peptidase IV enzyme in oral cancer patients and to ascertain if Dipeptidyl Peptidase IV can be used as a tumor marker in the early diagnosis of cancer. The study was performed on 31 patients with different stages of oral squamous cell carcinoma as a study group and 10 control healthy group. The mean DPP IV activity in study group was significantly lower than control group. Among the study group, well differentiated squamous cell carcinoma had the highest mean serum DPP IV activity than moderately and poorly differentiated squamous cell carcinoma. We hence conclude that DPP IV activity in serum can be used as a biochemical marker in the diagnosis of oral squamous cell carcinoma.
机译：二肽基肽酶IV（DPP IV）是从肽中分离出N末端X-脯氨酸的酶。这项研究的目的是提出一种可靠的测试方法，以定量评估口腔癌患者的血清二肽基肽酶IV酶，并确定二肽基肽酶IV是否可以用作癌症早期诊断中的肿瘤标志物。本研究以31例口腔鳞状细胞癌不同阶段的患者为研究组，另10例为对照组。研究组的平均DPP IV活性显着低于对照组。在研究组中，高分化鳞状细胞癌的平均血清DPP IV活性高于中分化和低分化鳞状细胞癌。因此，我们得出结论，血清中的DPP IV活性可用作生化标记物，用于诊断口腔鳞状细胞癌。

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