Novel dihydropyrimidine derivatives as antibacterial agents

Nevagi Reshma J; Narkhede Harsha I

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Novel dihydropyrimidine derivatives as antibacterial agents

机译：新型二氢嘧啶衍生物作为抗菌剂

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Novel dihydropyrimidine derivatives were synthesized and evaluated for antibacterial activity against Gram positive and negative bacterias. In the present study, synthesis involves the modification of dihydropyrimidine (DHPM) pharmacophore with thiosemicarbazide, semicarbazide functions. All the newly synthesized compounds were characterized by their spectral data and further used to estimate their ability towards antibacterial activity. Antibacterial activity was carried out by serial dilution method using Streptomycin as standard drug. Compound - (4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide (6C) showed comparable activity with the standard used.

机译：合成了新型的二氢嘧啶衍生物，并评估了其对革兰氏阳性和阴性细菌的抗菌活性。在本研究中，合成涉及用硫代氨基脲，氨基脲功能修饰二氢嘧啶（DHPM）药效团。所有新合成的化合物均通过其光谱数据进行了表征，并进一步用于评估其抗细菌活性的能力。使用链霉素作为标准药物，通过系列稀释法进行抗菌活性。化合物-（4-氯苯基）-6-甲基-2-氧代1,2,3,4-四氢嘧啶-5-碳酰肼（6C）具有与所用标准品相当的活性。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2014年第3期|共5页
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Nevagi Reshma J; Narkhede Harsha I;
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Novel dihydropyrimidine derivatives as antibacterial agents

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