Synthesis of novel N'-(2-oxoindolin-3-ylidene)benzofuran-2-carbohydrazides via greener approach and their biological activities

Bharti Bhardwaj; Subhash C. Jain

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Synthesis of novel N'-(2-oxoindolin-3-ylidene)benzofuran-2-carbohydrazides via greener approach and their biological activities

机译：新型N'-（2-氧代吲哚-3-亚基）苯并呋喃-2-碳酰肼的绿色合成及其生物活性

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A novel series of N′-(2-oxoindolin-3-ylidene)benzofuran-2-carbohydrazides was synthesized starting from substituted indoline-2,3-diones and benzofuran-2-carbohydrazide. The reaction was performed in water and the procedure was very simple and clean, as no use of any organic solvent or catalyst. This provides new opportunities for the rapid screening of a wide range of compounds, either for the development of new drugs, or original compounds for the material scientist. All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and were also evaluated for their biological activities.

机译：从取代的二氢吲哚-2,3-二酮和苯并呋喃-2-碳酰肼开始合成了一系列新的N'-（2-氧吲哚-3-基亚丙基）苯并呋喃-2-碳酰肼。该反应在水中进行，并且该过程非常简单和清洁，因为不使用任何有机溶剂或催化剂。这为快速筛选广泛的化合物提供了新的机会，无论是用于开发新药还是用于材料科学家的原始化合物。在详细的光谱研究的基础上，对所有合成的化合物进行了全面表征，并对它们的生物学活性进行了评估。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2014年第1期|共7页
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Bharti Bhardwaj; Subhash C. Jain;
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机译：（Z）-N' - （2-氧代吲哚啉-3-百少民）酰亚肼的CIS /烷酰胺旋转剂的合成，晶体结构和生物活性

Synthesis of novel N'-(2-oxoindolin-3-ylidene)benzofuran-2-carbohydrazides via greener approach and their biological activities

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