Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

Mashooq A. Bhat; Mohammed A. Al-Omar; Nadeem Siddiqui

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Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

机译：新型邻苯二甲酰亚胺1,3,4-恶二唑衍生物的合成，抗惊厥和神经毒性

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A series of novel 1,3,4-oxadiazole derivatives of phthalimide (4a-j) were prepared in satisfactory yields and evaluated for their anticonvulsant and neurotoxicity studies. All the compounds were in good agreement with elemental analysis and spectral data. All the compounds were active in MES screen and less neurotoxic than phenytoin. Compound 4j having methoxy substitution at para position of the distal aryl ring emerged as most promising anticonvulsant agent with low neurotoxicity.

机译：以令人满意的收率制备了一系列新型的邻苯二甲酰亚胺1,3,4-恶二唑衍生物（4a-j），并对其抗惊厥和神经毒性研究进行了评估。所有化合物与元素分析和光谱数据均吻合良好。所有化合物在MES筛选中均具有活性，并且神经毒性比苯妥英钠小。在远端芳基环的对位具有甲氧基取代的化合物4j作为具有低神经毒性的最有希望的抗惊厥剂出现。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2010年第2期|共10页
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Mashooq A. Bhat; Mohammed A. Al-Omar; Nadeem Siddiqui;
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Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

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