首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Development and Validation of UV Spectrophotometric Method for Estimation of Lamivudine in Bulk and Tablet Dosage Form
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Development and Validation of UV Spectrophotometric Method for Estimation of Lamivudine in Bulk and Tablet Dosage Form

机译:紫外分光光度法测定大剂量拉米夫定和片剂剂量法的建立和验证

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UV Spectrophotometric method has been developed for estimation of lamivudine in bulk and tablet dosage form by using water as solvent. Method developed is Area Under Curve (AUC) method. For analysis of lamivudine by AUC method the wavelength range selected was 265 nm to 275 nm because the linearity was obtained within this area with good reproducibility of results. Lamivudine shows absorbance maxima (λmax) at 271 nm scanned in UV range of 400 nm to 200 nm. Lamivudine obeys Beer’s law in the concentration range of 10-60 μg/ml.
机译:已经开发了紫外分光光度法,以水为溶剂估计拉米夫定的散装和片剂剂型。开发的方法是曲线下面积(AUC)方法。对于通过AUC方法进行拉米夫定分析,选择的波长范围为265 nm至275 nm,因为在该区域内获得了线性,结果具有良好的可重复性。拉米夫定显示在400 nm至200 nm的UV范围内扫描的271 nm处的最大吸光度(λmax)。拉米夫定在10-60μg/ ml的浓度范围内遵守比尔定律。

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