...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >6and#42892;,7and#42892;-Dihydroxybergamottin Promotes Collagen Synthesis by Activating the Smad Signaling Pathway in Human Dermal Fibroblasts
【24h】

6and#42892;,7and#42892;-Dihydroxybergamottin Promotes Collagen Synthesis by Activating the Smad Signaling Pathway in Human Dermal Fibroblasts

机译：6and＃42892;，7and＃42892;-二羟基香柠檬素通过激活人皮肤成纤维细胞中的Smad信号通路来促进胶原蛋白的合成

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Skin wrinkling appears to be principally related to decrease levels of type I collagen, elastin, and hyaluronic acid, the principal components of the dermal layer of skin. The cause of wrinkling and the appearance of the skin resulting from decreased elasticity and skin sagging and pigmentation, is generally associated with decreased collagen and increased collagenase and Matrix Metalloproteinase (MMP) activities. In this study, we investigated the possibility that 6ꞌ,7ꞌ-Dihydroxybergamottin (DHB) may be an effective anti-wrinkle agent. DHB is a natural component of furanocoumarin which is frequently observed in citrus fruits. Initially, up to 200 μM DHB was shown to be non-toxic to human dermal fibroblasts. Then, a human type I pro-collagen production assay was performed in human dermal fibroblast cells treated with 50, 100, and 200 μM DHB. The results showed that DHB significantly increased type I pro-collagen production. In addition, DHB strongly inhibited MMP-1 production in a concentration-dependent manner. DHB was also found to induce the phosphorylation of Smad2, an important transcription factor involved in the production of type I procollagen. These results suggest that DHB may be a potential anti-wrinkle agent for topical application in the cosmetic industry.
机译：皮肤起皱似乎主要与I型胶原蛋白，弹性蛋白和透明质酸（皮肤真皮层的主要成分）水平降低有关。弹性降低，皮肤下垂和色素沉着导致皱纹的原因和皮肤外观通常与胶原蛋白减少，胶原酶和基质金属蛋白酶（MMP）活性增加有关。在这项研究中，我们调查了6ꞌ，7ꞌ-二羟基香柠檬素（DHB）可能是有效的抗皱剂的可能性。 DHB是呋喃香豆素的天然成分，经常在柑橘类水果中观察到。最初，高达200μM的DHB被证明对人皮肤成纤维细胞无毒。然后，在用50、100和200μMDHB处理的人皮肤成纤维细胞中进行人I型胶原原生产试验。结果显示DHB显着增加了I型促胶原蛋白的产生。此外，DHB以浓度依赖的方式强烈抑制MMP-1的产生。还发现DHB可以诱导Smad2的磷酸化，Smad2是参与I型前胶原产生的重要转录因子。这些结果表明，DHB可能是在化妆品工业中局部应用的潜在抗皱剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号