Synthesis and In Vitro anthelmintic activity of novel substituted oxadiazole bearing benzimidazole derivatives.

Neetu Soni; Namrata Soni; Pushpraj Gupta

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Synthesis and In Vitro anthelmintic activity of novel substituted oxadiazole bearing benzimidazole derivatives.

机译：新型取代的含恶二唑的苯并咪唑衍生物的合成及体外驱虫活性。

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Nitrogen containing heterocycles drawn special attention in pharmaceutical chemistry due to their excellent medicinal potential. A novel series of substituted oxadiazole derivatives of benzimidazole synthesize in the correlation of anthelmintic activity, all the products were assayed against Pheretima posthuma. Out of the twelve synthesized derivatives, five compounds (6d, 6c, 7a, 7c, 7d) showed anthelmintic activity in a dose-dependent manner giving shortest time of paralysis and death with different concentrations. Among these, two derivatives, 6c and 6d showed superior activity.

机译：含氮杂环由于其极好的药用潜力而在药物化学中引起了特别关注。在驱虫活性的相关性上合成了一系列新的苯并咪唑取代的恶二唑衍生物系列，所有产物均经过了抗腐皮霉的测定。在十二种合成衍生物中，五种化合物（6d，6c，7a，7c，7d）以剂量依赖性方式显示出驱虫活性，并在不同浓度下使麻痹和死亡时间最短。其中，两种衍生物6c和6d表现出优异的活性。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2016年第7期|共4页
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Neetu Soni; Namrata Soni; Pushpraj Gupta;
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Synthesis and In Vitro anthelmintic activity of novel substituted oxadiazole bearing benzimidazole derivatives.

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