Design and Synthesis of 1-(3a??,5a??-bis trifluoromethyl phenyl)-3-(substituted phenyl)-2-propene-1-one as potent antifungal and antibacterial agents

Ch. M. M. Prasada Rao; S. A. Rahaman; Y. Rajendra Prasad; G Eswara Rao

首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Design and Synthesis of 1-(3a??,5a??-bis trifluoromethyl phenyl)-3-(substituted phenyl)-2-propene-1-one as potent antifungal and antibacterial agents

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Design and Synthesis of 1-(3a??,5a??-bis trifluoromethyl phenyl)-3-(substituted phenyl)-2-propene-1-one as potent antifungal and antibacterial agents

机译：1-（3aβ，5aβ-双三氟甲基苯基）-3-（取代的苯基）-2-丙烯-1-酮作为有效的抗真菌和抗菌剂的设计与合成

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Seven new chalcones were synthesised by Claisen Schmidt condensation using 3,5-bis- trifluoromethyl acetophenone with aromatic aldehydes in dilute ethanolic potassium hydroxide solution at room temperature. All these compounds were characterised by means of their IR, 1H NMR Spectroscopic data and Elemental analysis. The antibacterial activity of these compounds were evaluated by cup plate method using Streptomycin as standard drug. The obtained zone of inhibition values showed that synthesized compounds are moderately significant. It is evident that the compound TFEA showed maximum antifungal activity when comparable with standard Ketoconazole.

机译：在室温下，在稀乙醇氢氧化钾溶液中，使用3,5-双-三氟甲基苯乙酮与芳香族醛，通过Claisen Schmidt缩合反应合成了七个新的查耳酮。所有这些化合物均通过其IR，1H NMR光谱数据和元素分析进行了表征。使用链霉素作为标准药物，通过杯板法评价了这些化合物的抗菌活性。所获得的抑制值区域显示合成的化合物具有中等重要性。显然，当与标准酮康唑相当时，化合物TFEA表现出最大的抗真菌活性。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2012年第5期|共6页
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Ch. M. M. Prasada Rao; S. A. Rahaman; Y. Rajendra Prasad; G Eswara Rao;
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机译：1-（3'，5'-双三氟甲基苯基）-3-（取代苯基）-2-丙烯-1-酮作为有效的抗真菌和抗菌剂的设计与合成
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Design and Synthesis of 1-(3a??,5a??-bis trifluoromethyl phenyl)-3-(substituted phenyl)-2-propene-1-one as potent antifungal and antibacterial agents

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