Synthesis and biological activity of 4-bromo-2-hydroxy-N-(5- methylene-4-oxo-2-aryl-thiazolidin-3-yl) benzamide

Sonal Maheta

首页> 外文期刊>Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry >Synthesis and biological activity of 4-bromo-2-hydroxy-N-(5- methylene-4-oxo-2-aryl-thiazolidin-3-yl) benzamide

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Synthesis and biological activity of 4-bromo-2-hydroxy-N-(5- methylene-4-oxo-2-aryl-thiazolidin-3-yl) benzamide

机译：4-溴-2-羟基-N-（5-亚甲基-4-氧代-2-芳基-噻唑烷-3-基）苯甲酰胺的合成及生物活性

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4-bromo-2-hydroxy benzoic acid hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-bromo-2-hydroxy benzoic acid arylidene hydrazides (2a-h) in good yields. Cyclocondensation of compounds (2a-h) with thioglycolic acid yields 4-bromo-2-hydroxy- N (4-oxo-2-aryl- thiazolidin -3-yl) benzamides (3a-h). These (3a-h) compounds are for the reacted with benzaldehyde in the presence of sodium ethanolate affords, giving 4-bromo-2-hydroxy- N (5-methylene-4-oxo-2-aryl- thiazolidin -3- yl)benzamides (4a-h). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

机译：4-溴-2-羟基苯甲酸酰肼（1）与芳族醛容易缩合，以高收率得到相应的4-溴-2-羟基苯甲酸苯乙酰肼（2a-h）。化合物（2a-h）与巯基乙酸的环缩合反应生成4-溴-2-羟基-N（4-氧代-2-芳基-噻唑烷-3-基）苯甲酰胺（3a-h）。这些（3a-h）化合物在乙醇钠存在下与苯甲醛反应，得到4-溴-2-羟基-N（5-亚甲基-4-氧代-2-芳基-噻唑烷-3-基）苯甲酰胺（4a-h）。这些化合物的结构是根据分析和光谱数据确定的。评价所有新合成的化合物的抗菌和抗真菌活性。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2010年第6期|共7页
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Sonal Maheta;
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中图分类化学;
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Synthesis and biological activity of 4-bromo-2-hydroxy-N-(5- methylene-4-oxo-2-aryl-thiazolidin-3-yl) benzamide

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