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首页> 外文期刊>Dhaka University Journal of Pharmaceutical Sciences >Neuroprotective Properties of Nigella sativa (L.) Seeds Extract in Sprague Dawley Rats models
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Neuroprotective Properties of Nigella sativa (L.) Seeds Extract in Sprague Dawley Rats models

机译：黑豆种子提取物在Sprague Dawley大鼠模型中的神经保护特性

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Neuroinflammation has been closely linked to neurodegeneration that leads to dysfunction of memory and learning where glial fibrillary acidic protein (GFAP) plays important role positively within hippocampus. In experimental neurodegeneration achieved by two-vessel occlusion (2VO) intervention, Nigella sativa (L.) seeds extract (50 mg/kg/day orally) has shown to have anti-neuroinflammatory and antioxidant properties. The brain hippocampal tissues were humanely collected at the end of 10th treatment week and preserved in Allprotect ? reagent at –80 ° C. Total RNA was extracted and purified by phenol/chloroform method using kits and reverse transcribed into cDNA and relatively quantified as per ΔΔCq. The NSSE treatment showed significantly (p&0.001) different relative GFAP mRNA expression in the treated group as compared to that of untreated 2VO whilst it was insignificantly (p&0.5) different to that of healthy control (HC). Prolonged or daily treatment with NSSE ( Nigella sativa (L.) seeds extract) may provide moderate anti-neuroprotective activity within hippocampus. Dhaka Univ. J. Pharm. Sci. 17(1): 113-121, 2018 (June).
机译：神经炎症与神经变性密切相关，神经变性导致记忆和学习功能障碍，其中神经胶质原纤维酸性蛋白（GFAP）在海马中积极发挥重要作用。在通过两血管闭塞（2VO）干预实现的实验性神经退行性变中，Nigella sativa（L.）种子提取物（50 mg / kg /天口服）具有抗神经炎和抗氧化特性。在第10个治疗周结束时人性化收集大脑海马组织，并保存在Allprotect？中。试剂在–80°C下进行提取。使用试剂盒通过苯酚/氯仿方法提取和纯化总RNA，反转录为cDNA，并根据ΔΔCq进行相对定量。与未治疗的2VO相比，NSSE治疗在治疗组中显示出显着（p ＜0.001）的相对GFAP mRNA表达，而与健康对照（HC）相比则无显着（p＞ 0.5）。长期或每日用NSSE（黑豆种子提取物）治疗可在海马体内提供中等程度的抗神经保护活性。达卡大学。 J.药物科学17（1）：113-121，2018（六月）。

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