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HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma

机译：HLA-G和HLA-E特异性mRNA在肾细胞癌中预示相反的预后意义

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Background Renal cell carcinoma (RCC) is characterized by its resistance to radiotherapy and/or chemotherapy. On the other hand, it is an immunogenic tumor - it is able to stimulate antitumor responses. A prognostic significance of HLA-G expression by neoplastic cells in RCC is not well characterized; significance HLA-E expression in RCC is not characterized at all. Methods In our study, we evaluated the expression of HLA-G and HLA-E specific mRNA transcripts produced by neoplastic cells in 38 cases of RCC and in 10 samples of normal kidney parenchyma. The results were statistically correlated with various clinico-pathological parameters. Results We confirmed that HLA-G is downregulated in normal kidney tissue; if it is up-regulated in RCC, then it is connected to worse prognosis. On the other hand, HLA-E mRNA transcripts were present in both normal kidney tissue and RCC and their increasing concentrations counterintuitively carried better prognosis, more favorable pT stage and lower nuclear Fuhrmann’s grade. Conclusion Considering the fact that there is known aberrant activation of HLA-G and HLA-E expression by interferons, identification of HLA-G and HLA-E status could contribute to better selection of RCC patients who could possibly benefit from more tailored neoadjuvant biological/immunological therapy. Thus, these molecules could represent useful prognostic biomarkers in RCC, and the expression of both these molecules in RCC deserves further study. The virtual Slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/ webcite7383071387016614
机译：背景技术肾细胞癌（RCC）的特征在于其对放射疗法和/或化学疗法的抵抗力。另一方面，它是一种免疫原性肿瘤-能够刺激抗肿瘤反应。 RCC中肿瘤细胞表达HLA-G的预后意义尚不清楚。 RCC中HLA-E的表达根本没有特征。方法在本研究中，我们评估了38例RCC和10例正常肾实质中肿瘤细胞产生的HLA-G和HLA-E特异性mRNA转录物的表达。结果与各种临床病理参数在统计学上相关。结果我们证实正常肾脏组织中HLA-G被下调;如果它在RCC中被上调，则预后较差。另一方面，正常肾脏组织和RCC中均存在HLA-E mRNA转录本，其含量的增加与直觉相反，预后较好，pT分期更有利，Fuhrmann核分级较低。结论考虑到已知干扰素可异常激活HLA-G和HLA-E表达的事实，鉴定HLA-G和HLA-E的状态可能有助于更好地选择RCC患者，这些患者可能会从更适合的新辅助生物学/治疗中受益。免疫治疗。因此，这些分子可能代表了RCC中有用的预后生物标志物，这两种分子在RCC中的表达值得进一步研究。可以在这里找到本文的虚拟幻灯片：http://www.diagnosticpathology.diagnomx.eu/vs/ webcite7383071387016614

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