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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: an unexpected prognostic significance?
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Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: an unexpected prognostic significance?

机译：胶质母细胞瘤中肿瘤细胞表达免疫调节分子HLA-G和HLA-E：预料不到的预后意义？

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摘要

The role of nonclassical human leukocyte antigens G and E (HLA-G and HLA-E) was originally thought to be restricted to the protection of the fetus from a maternal allorecognition. Now it is known that HLA-G and HLA-E exert multiple immunoregulatory functions. A prognostic significance of the expression of HLA-G and HLA-E by neoplastic cells in glioblastoma is not well characterized. In this study, we evaluated the expression of HLA-G and HLA-E by neoplastic cells in 39 cases of glioblastoma. We found the production of HLA-G and HLA in a majority of cases. There was an unexpected positive correlation between the expression of HLA-E and length of survival. We speculate that the expression of this molecule by neoplastic cells may represent a coincidental selective pro-host advantage related to better response to subsequent therapeutic modalities. Mechanisms of glioblastoma cell pathophysiology and mechanisms of responses to therapeutic interventions in respect to the expression of these molecules deserves further study.
机译：最初认为非经典人类白细胞抗原G和E（HLA-G和HLA-E）的作用仅限于保护胎儿免受母体同种异体认知。现在已知HLA-G和HLA-E发挥多种免疫调节功能。胶质母细胞瘤中肿瘤细胞表达HLA-G和HLA-E的预后意义尚不明确。在这项研究中，我们评估了39例胶质母细胞瘤中肿瘤细胞的HLA-G和HLA-E的表达。在大多数情况下，我们发现了HLA-G和HLA的产生。 HLA-E的表达与生存期之间存在出乎意料的正相关。我们推测，肿瘤细胞表达该分子可能代表与对后续治疗方式更好的反应有关的巧合的选择性前宿主优势。关于这些分子的表达，胶质母细胞瘤细胞病理生理机制和对治疗干预的反应机制值得进一步研究。

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