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首页> 外文期刊>Dhaka University Journal of Pharmaceutical Sciences >Studies of the Effect of Storage Conditions on Some Pharmaceutical Parameters of Powders and Tablets
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Studies of the Effect of Storage Conditions on Some Pharmaceutical Parameters of Powders and Tablets

机译：贮藏条件对散剂和片剂某些药理参数影响的研究

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This study evaluates the effect of storage conditions on some pharmaceutical parameters of powders (paracetamol, corn starch, tragacanth and polyvinyl pyrrolidone) and tablets (paracetamol, metronidazole and vitamin C). For powdered samples, angle of repose, bulk and tapped densities were determined while the tablets were evaluated for hardness, friability and disintegration before and after exposure to various humidity conditions, radiations from telecommunication mast and sunlight at intervals of 24 hrs & 1, 2, 4 and 8 weeks. The results showed a decrease in the angle of repose for paracetamol, corn starch, polyvinyl pyrollidone and tragacanth powders on exposure to sunlight. There was no significant (p>0.05) change in the tapped and bulk densities under the different storage conditions over the storage period. No organoleptic changes were observed for any of the samples stored under the environmental conditions over the two-month period. All the tablets stored over the two- month period conformed to the official BP standard for weight uniformity. Paracetamol tablets exposed to 93% relative humidity (RH) showed significantly lower reduction (P<0.05) in hardness compared to the other storage conditions. On prolonged exposure of paracetamol and metronidazole tablets to radiation from telecommunication mast, there was a reduction in tablet hardness and the tablets became friable. The observations of the present study reconfirm the role of storage conditions in ensuring the physical stability of pharmaceutical powders and tablets.Dhaka Univ. J. Pharm. Sci. 14(2): 147-151, 2015 (December)
机译：这项研究评估了贮藏条件对粉末（对乙酰氨基酚，玉米淀粉，黄can胶和聚乙烯吡咯烷酮）和片剂（对乙酰氨基酚，甲硝唑和维生素C）某些药物参数的影响。对于粉状样品，测定片剂的休止角，堆积密度和螺孔密度，同时评估片剂在暴露于各种湿度条件，电信桅杆的辐射和日光照射前后的硬度，易碎性和崩解性，间隔为24小时和1、2。 4和8周。结果表明，暴露在阳光下，扑热息痛，玉米淀粉，聚乙烯吡咯烷酮和黄aga胶粉的休止角减小。在不同的存储条件下，整个存储期间的堆积密度和堆积密度无显着变化（p> 0.05）。在两个月内在环境条件下存储的任何样品均未观察到感官变化。在两个月内储存的所有片剂均符合官方BP标准的重量均匀性标准。相对于其他储存条件，对乙酰氨基酚片剂暴露在93％的相对湿度（RH）下，硬度降低幅度明显更低（P <0.05）。在对乙酰氨基酚和甲硝唑片剂长时间暴露于电信桅杆的辐射中后，片剂硬度降低，片剂变得易碎。本研究的观察结果再次证实了储存条件在确保药物粉剂和片剂的物理稳定性中的作用。 J.药物科学14（2）：147-151，2015（12月）

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