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首页> 外文期刊>Diagnostic and therapeutic endoscopy >Bowel Preparation for Colonoscopy with Sodium Phosphate Solution versus Polyethylene Glycol-Based Lavage: A Multicenter Trial
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Bowel Preparation for Colonoscopy with Sodium Phosphate Solution versus Polyethylene Glycol-Based Lavage: A Multicenter Trial

机译：用磷酸钠溶液与聚乙二醇为基础的灌肠进行结肠镜检查的肠道准备：一个多中心试验

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Background: Adequate bowel preparation is essential foraccurate colonoscopy. Both oral sodium phosphate (NaP) andpolyethylene glycol-based lavage (PEG-ELS) are used predominantlyas bowel cleansing modalities. NaP has gained popularity due tolow drinking volume and lower costs. The purpose of thisrandomized multicenter observer blinded study was to comparethree groups of cleansing (NaP, NaP + sennosides, PEG-ELS +sennosides) in reference to tolerability, acceptance, andcleanliness. Patient and Methods: 355 outpatients between 18 and75 years were randomized into three groups (A, B, C) receiving NaP =A, NaP, and sennosides = B or PEG-ELS and sennosides = C.Gastroenterologists performing colonoscopies were blinded to thetype of preparation. All patients documented tolerance and adverseevents. Vital signs, premedication, completeness, discomfort, andcomplications were recorded. A quality score (0–4) of cleanlinesswas generated.Results: The three groups were similarwith regard to age, sex, BMI, indication for colonoscopy, andcomorbidity. Drinking volumes (L) (A = 4.33 + 1.2, B = 4.56 + 1.18, C = 4.93 + 1.71) were in favor of NaP(P= .005). Discomfort fromingested fluid was recorded in A = 39.8% (versus C:P= .015), B = 46.6% (versus C:P= .147), and C = 54.6%. Differences in tolerability and acceptance between the three groups werestatistically not significant. No differences in adverse eventsand the cleanliness effects occurred in the three groups (P= .113).The cleanliness quality scores 0–2 were calculated in A:77.7%, B: 86.7%, and C: 85.2%.Conclusions:These data fail to demonstrate significant differences intolerability, acceptance, and preparation quality between thethree types of bowel preparation for colonoscopy. Cleansing withNaP was not superior to PEG-ELS.
机译：背景：充分的肠道准备对于准确的结肠镜检查必不可少。口服磷酸钠（NaP）和聚乙二醇基灌洗液（PEG-ELS）都主要用作肠道清洁方式。由于饮水量少和成本低，NaP受到欢迎。这项随机化的多中心观察者双盲研究的目的是比较三组清洁剂（NaP，NaP +苦参皂苷，PEG-ELS +苦参皂苷）的耐受性，可接受性和清洁度。患者和方法：将355名18至75岁的门诊患者随机分为三组（A，B，C），分别接受NaP = A，NaP和sennosides = B或PEG-ELS和sennosides = C.进行结肠镜检查的胃肠病学家对制备。所有患者均记录有耐受性和不良事件。记录生命体征，用药前，完整性，不适和并发症。结果：清洁度的质量得分为（0–4）。结果：这三组患者的年龄，性别，BMI，结肠镜检查适应症和合并症相似。饮酒量（L）（A = 4.33 + 1.2，B = 4.56 + 1.18，C = 4.93 + 1.71）有利于NaP（P = .005）。摄食引起的不适感记录为A = 39.8％（相对于C：P = .015），B = 46.6％（相对于C：P = .147）和C = 54.6％。三组之间的耐受性和接受性差异在统计学上不显着。三组的不良事件和清洁效果均无差异（P = .113）。清洁质量得分0–2的计算分别为A：77.7％，B：86.7％和C：85.2％。结论：这些数据未能证明三种结肠镜检查肠道准备之间的不耐受性，可接受性和准备质量有显着差异。用NaP清洗并不优于PEG-ELS。

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