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首页> 外文期刊>The Egyptian Journal of Hospital Medicine >Prevalence of Glucose-6-Phosphate Dehydrogenase and Thyroid Hormones Deficiency in Neonatal Jaundice
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Prevalence of Glucose-6-Phosphate Dehydrogenase and Thyroid Hormones Deficiency in Neonatal Jaundice

机译：新生儿黄疸中6-磷酸葡萄糖脱氢酶和甲状腺激素缺乏症的患病率

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G6PD deficiency is the most common inherited metabolic disorder and clinically significant red cell enzyme defect in man. Severe neonatal jaundice proved to be the most common clinical manifestation and a globally important most dangerous consequence of G6PD deficiency. Prolonged jaundice is sometimes associated with congenital hypothyroidism. So the early characterization of G6PD activity and thyroid hormone levels provides an etiological diagnosis for neonatal jaundice as well as the opportunity to give the newborn's family information concerning hemolytic crisis prevention and an early management in case of hypothyroidism. Aim : This study was conducted in an attempt to evaluate the prevalence of G6PD deficiency and hypothyroidism in relation to neonatal physiological hyperbilirubinemia. Subjects and Methods: The study included 50 neonates aged between 6 hr - 5 days, forty infants had jaundice and the other ten (control), were healthy neonates, matching the same age. All infants of the study were subjected to C-RP test, routine hematological evaluation, and serum total bilirubin levels, quantitative red blood cells G6PD assay and thyroid hormone levels. Results: All the fifty cases of both jaundiced and healthy neonates were negative for C-RP test indicating that the 40 cases had physiological jaundice .The study revealed that G6PD enzyme was lower than normal level in 2 cases (5%). TSH level was found to be higher than normal in 13 jaundiced neonates out of 40 (33%). Seven jaundiced neonates (18%) had T4 hormone lower than normal while all the 40 jaundiced cases had normal T3 level. Correlation of the total bilirubin was significant with TSH and T3 at 0.05 levels, while there was no significance with both T4 and G6PD. Conclusion: statistically there was no correlation between bilirubin and both G6PD enzyme and thyroid hormones, but the incidence of hypothyroidism in this study was high (18%) and the incidence of G6PD deficiency was (5%). This indicates a role of G6PD deficiency and hypothyroidism in developing neonatal jaundice among neonates. So, early neonatal screening program is recommended for early management
机译：G6PD缺乏症是人类最常见的遗传性代谢紊乱，是临床上明显的红细胞酶缺陷。严重的新生儿黄疸被证明是G6PD缺乏症最常见的临床表现，也是全球重要的最危险后果。长期黄疸有时与先天性甲状腺功能减退有关。因此，早期表征G6PD活性和甲状腺激素水平可为新生儿黄疸提供病因诊断，并有机会向新生儿的家庭提供有关预防溶血危机的信息，并在甲状腺功能减退的情况下及早进行治疗。目的：进行这项研究旨在评估与新生儿生理性高胆红素血症有关的G6PD缺乏症和甲状腺功能低下的患病率。研究对象和方法：研究对象为50例6小时至5天之间的新生儿，其中40例患黄疸的婴儿，其余10例（对照组）均为健康的婴儿，年龄相同。研究的所有婴儿均接受了C-RP测试，常规血液学评估，血清总胆红素水平，定量红细胞G6PD测定和甲状腺激素水平。结果：50例黄疸型和健康型新生儿的C-RP试验均为阴性，表明40例患有生理性黄疸。研究表明，G6PD酶低于正常水平的2例（5％）。在40名（33％）的13名黄疸新生儿中，TSH水平高于正常水平。 7名黄疸新生儿（18％）的T4激素水平低于正常水平，而所有40例黄疸新生儿的T3水平均正常。 TSH和T3在0.05水平时，总胆红素的相关性显着，而T4和G6PD两者均无显着性。结论：统计学上胆红素与G6PD酶和甲状腺激素均无相关性，但本研究中甲状腺功能减退的发生率高（18％），而G6PD缺乏症的发生率（5％）。这表明G6PD缺乏症和甲状腺功能减退症在新生儿新生儿黄疸中的作用。因此，建议早期新生儿筛查计划以进行早期治疗

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