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首页> 外文期刊>Diagnostic and therapeutic endoscopy >Helicobacter Pylori Associated Antral Gastritis in Peptic Ulcer Disease Patients and Normal Healthy Population of Kashmir, India
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Helicobacter Pylori Associated Antral Gastritis in Peptic Ulcer Disease Patients and Normal Healthy Population of Kashmir, India

机译：印度克什米尔的消化性溃疡病患者和正常健康人群的幽门螺杆菌相关性胃窦炎

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Aim: To study the association of Helicobacter pylori infection with chronic antralgastritis in peptic ulcer disease patients and healthy population of Kashmir.Methods: 50 peptic ulcer patients (duodenal ulcer = 46, gastric ulcer = 2 and combinedduodenal and gastric ulcer = 2) and 30 asymptomatic healthy volunteers were included inthis study. Peptic ulcer was diagnosed on endoscopic examination. 4–6 punch biopsieswere taken from gastric antrum in all the individuals and in case of gastric ulcer anadditional biopsy was taken from the edge of the ulcer to exclude its malignant nature.Helicobacter pylori (H. pylori) organism was diagnosed using three different test methods,viz. Histology (using Giemsa Stain), Microbiology (Gram Stain) and Biochemistry(using one minute Endoscopy Room Test). Histological diagnosis of H. pylori was takenas the “gold standard” for the presence of H. pylori organism. Histological diagnosis ofgastritis was made using Hematoxylin and Eosin Stain and the gastritis was classifiedas active chronic gastritis and superficial chronic gastritis.Results: Out of 30 peptic ulcer disease patients with associated antral gastritis, 27 (90%) were positive for H. pylori on histological examination (13 superficial chronicgastritis and 14 active chronic gastritis) whereas out of 8 healthy volunteers withhistological evidence of chronic antral gastritis, H. pylori was observed in 7 individuals(87.50%) (4 active chronic gastritis and 3 superficial chronic gastritis).Conclusion: A highly significant association between H. pylori infection with chronicantral gastritis both in peptic ulcer disease patients and healthy volunteers of Kashmirwas found in this study. Association between H. pylori infection and chronic gastritiswas 90% in peptic ulcer group and 87.50% in healthy population(P<0.005).
机译：目的：研究消化性溃疡病患者和克什米尔健康人群的幽门螺杆菌感染与慢性胃窦炎的关系。方法：50例消化性溃疡患者（十二指肠溃疡= 46，胃溃疡= 2，十二指肠胃溃疡合并= 2）和30无症状的健康志愿者包括在这项研究中。内镜检查诊断为消化性溃疡。所有患者均从胃窦进行4–6次穿刺活检，如果发生胃溃疡，则应从溃疡边缘进行额外的活检以排除其恶性。使用三种不同的测试方法对幽门螺杆菌（H. pylori）进行诊断。 ，即组织学（使用Giemsa染色），微生物学（使用Gram染色）和生物化学（使用一分钟内窥镜室内测试）。幽门螺杆菌的组织学诊断被视为存在幽门螺杆菌的“金标准”。应用苏木精和曙红染色对胃炎进行组织学诊断，并将胃炎分为活动性慢性胃炎和浅表性慢性胃炎。结果：30例伴有胃窦炎的消化性溃疡病患者中，有27例（90％）幽门螺杆菌组织学阳性。检查（13例浅表性慢性胃炎和14例活动性慢性胃炎），而在8名有慢性胃窦炎组织学证据的健康志愿者中，有7例（87.50％）观察到幽门螺杆菌（4例活动性慢性胃炎和3例浅表性慢性胃炎）。这项研究发现，在消化性溃疡疾病患者和克什米尔的健康志愿者中，幽门螺杆菌感染与慢性胃炎之间存在高度显着的关联。消化性溃疡组幽门螺杆菌感染与慢性胃炎的相关性为90％，健康人群为87.50％（P <0.005）。

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