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首页> 外文期刊>Drug Design, Development and Therapy >Discovery, development, and clinical application of sugammadex sodium, a selective relaxant binding agent
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Discovery, development, and clinical application of sugammadex sodium, a selective relaxant binding agent

机译：舒张糊精钠（一种选择性松弛剂结合剂）的发现，开发和临床应用

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Abstract: Neuromuscular blockade, induced by neuromuscular blocking agents, has allowed prescribed immobility, improved surgical exposure, optimal airway management conditions, and facilitated mechanical ventilation. However, termination of the effects of neuromuscular blocking agents has, until now, remained limited. A novel cyclodextrin encapsulation process offers improved termination of the paralytic effects of aminosteroidal non-depolarizing neuromuscular blocking agents. Sugammadex sodium is the first in a new class of drug called selective relaxant binding agents. Currently, in clinical trials, sugammadex, a modified gamma cyclodextrin, has shown consistent and rapid termination of neuromuscular blockade with few side effects. The pharmacology of cyclodextrins in general and sugammadex in particular, together with the results of current clinical research are reviewed. The ability of sugammadex to terminate the action of neuromuscular blocking agents by direct encapsulation is compared to the indirect competitive antagonism of their effects by cholinesterase inhibitors. Also discussed are the clinical implications that extend beyond fast, effective reversal, including numerous potential peri-operative benefits.
机译：摘要：由神经肌肉阻滞剂引起的神经肌肉阻滞已允许规定的固定性，改善了手术暴露，优化了气道管理条件，并促进了机械通气。然而，迄今为止，神经肌肉阻滞剂作用的终止仍然有限。一种新颖的环糊精包封工艺改善了氨基甾体非去极化神经肌肉阻滞剂麻痹作用的改善。 Sugammadex钠是新型药物中的第一个，称为选择性松弛剂结合剂。目前，在临床试验中，改良的γ-环糊精sugammadex已显示出稳定而迅速地终止神经肌肉阻滞作用，且几乎没有副作用。综述了环糊精的一般药理作用，特别是sugammadex的药理作用，以及当前的临床研究结果。 sugammadex通过直接包封终止神经肌肉阻断剂作用的能力与通过胆碱酯酶抑制剂对其作用的间接竞争拮抗作用进行了比较。还讨论了超越快速，有效逆转的临床意义，包括许多潜在的围手术期益处。

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