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首页> 外文期刊>Current opinion in anaesthesiology >Sugammadex: a selective relaxant-binding agent providing rapid reversal.
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Sugammadex: a selective relaxant-binding agent providing rapid reversal.

机译：Sugammadex：一种选择性的松弛剂结合剂，可快速逆转。

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摘要

PURPOSE OF REVIEW: Sugammadex is a new reversal agent with a unique mechanism of action in anaesthesia. Because of its rapid onset of action and its efficacy in determining neuromuscular blockade at any time, it opens up new perspectives in anaesthesia. RECENT FINDINGS: During the last few years, a lot of phase II and III studies have been published, investigating various groups of patients and clinical situations. Sugammadex has been shown to be a well tolerated drug, which appears to meet every challenge it is presented with in daily clinical practice. SUMMARY: Sugammadex binds amino-steroidal muscle relaxants by encapsulation. It enables rapid reversal of neuromuscular blockade at any time point and at any depth of block. Its effects are predictable and very reliable, in contrast to cholinesterase inhibitors. This opens up new perspectives in anaesthesia. Even an emergency reversal of high-dose rocuronium-induced neuromuscular blockade is possible with sugammadex and times to full recovery (TOF 0.9) are faster than after spontaneous recovery from suxamethonium.
机译：审查目的：Sugammadex是一种具有独特麻醉作用机理的新型逆转剂。由于其起效迅速，并且可以随时确定神经肌肉阻滞的功效，因此为麻醉开辟了新的前景。最近的发现：在过去的几年中，已经发布了许多II期和III期研究，以调查各种类型的患者和临床情况。 Sugammadex已被证明是一种耐受性良好的药物，似乎可以应付日常临床实践中遇到的所有挑战。摘要：Sugammadex通过封装结合氨基甾体肌肉松弛剂。它可以在任何时间点和任何深度的神经肌肉阻滞快速逆转。与胆碱酯酶抑制剂相比，其作用是可预测的并且非常可靠。这为麻醉开辟了新的视角。舒美葡糖甚至可以紧急逆转大剂量罗库溴铵诱导的神经肌肉阻滞，并且完全恢复的时间（TOF 0.9）比从琥珀酸自发恢复后要快。

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