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首页> 外文期刊>Drug Design, Development and Therapy >Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications
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Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications

机译：肽激素输送用水凝胶：治疗和组织工程应用

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Peptides are the most abundant biological compounds in the cells that act as enzymes, hormones, structural element, and antibodies. Mostly, peptides have problems to move across the cells because of their size and poor cellular penetration. Therefore, a carrier that could transfer peptides into cells is ideal and would be effective for disease treatment. Until now, plenty of polymers, e.g., polysaccharides, polypeptides, and lipids were used in drug delivery. Hydrogels made from polysaccharides showed significant development in targeted delivery of peptide hormones because of their natural characteristics such as networks, pore sizes, sustainability, and response to external stimuli. The main aim of the present review was therefore, to gather the important usages of the hydrogels as a carrier in peptide hormone delivery and their application in tissue engineering and regenerative medicine.
机译：肽是细胞中最丰富的生物化合物，可充当酶，激素，结构元件和抗体。通常，由于肽的大小和不良的细胞渗透性，它们在跨细胞移动方面存在问题。因此，可以将肽转移到细胞中的载体是理想的，并且对于疾病治疗是有效的。迄今为止，药物递送中使用了大量的聚合物，例如多糖，多肽和脂质。由多糖制成的水凝胶由于其天然特性（例如网络，孔径，可持续性和对外部刺激的反应）而在肽激素的靶向递送方面显示出显着发展。因此，本综述的主要目的是收集水凝胶作为载体在肽激素输送中的重要用途及其在组织工程和再生医学中的应用。

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