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首页> 外文期刊>Dose-response >Hormesis as a Pro-Healthy Aging Intervention in Human Beings?
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Hormesis as a Pro-Healthy Aging Intervention in Human Beings?

机译：作为人类对健康有益的老龄化干预的药物？

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摘要

Hormesis is a phenomenon in which adaptive responses to low doses of otherwise harmful factors (also called mild stressors) make cells and organisms more robust. Aging is a complex and poorly understood process. This review explores the positive effects of hormesis on aging in animal models and human cell cultures, and discusses whether it might apply to humans. As an example, repeated mild heat stress confers anti-aging benefits to normal human cells in culture. Calorie restriction and xenohormetic compounds such as resveratrol, in large part via activation of sirtuins, decrease risk of common age-related conditions, such as cancer, cardiovascular disease, type 2 diabetes, and neurological diseases, so lengthening lifespan. Mild stressors and xenohormetic dietary components have diverse molecular targets and affect many pathways. Despite experimental advances in aging research, findings in humans are still quite limited. Moderate-intensity exercise, weight management and healthy diet ameliorate diseases of aging to increase lifespan and this could involve hormesis.
机译：兴奋剂是一种现象，其中对低剂量的其他有害因素（也称为轻度压力源）的适应性反应会使细胞和生物体更加健壮。衰老是一个复杂且鲜为人知的过程。这篇综述探讨了兴奋剂对动物模型和人类细胞培养物中衰老的积极影响，并讨论了它是否可能适用于人类。例如，反复的轻度热应激赋予培养中正常人细胞抗衰老的好处。热量限制和异乎寻常的化合物（如白藜芦醇）主要是通过激活沉默调节蛋白来降低常见的与年龄有关的疾病（如癌症，心血管疾病，2型糖尿病和神经系统疾病）的风险，因此可以延长寿命。轻度压力源和异乎寻常的饮食成分具有多种分子靶标，并影响许多途径。尽管衰老研究在实验上取得了进展，但人类的发现仍然非常有限。进行中等强度的锻炼，控制体重和健康饮食可改善衰老疾病，从而延长寿命，这可能涉及兴奋剂。

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