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首页> 外文期刊>JA Clinical Reports >A case of Kounis syndrome presenting as coronary artery spasm associated with cefazolin-induced anaphylaxis during general anesthesia
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A case of Kounis syndrome presenting as coronary artery spasm associated with cefazolin-induced anaphylaxis during general anesthesia

机译：一例Kounis综合征表现为全麻期间头孢唑林致过敏反应伴冠状动脉痉挛

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Abstract BackgroundKounis syndrome (KS) is defined as the occurrence of acute coronary syndrome (ACS) associated with an anaphylactic reaction, and there have only been a few reports of its occurrence under general anesthesia.Case presentationA 69-year-old woman underwent transurethral resection of a bladder tumor under general anesthesia. Cefazolin was administered intravenously after induction of general anesthesia. During the operation, we suspected ACS from sudden ST segment depression on electrocardiogram. The delayed onset of an erythematous rash reminded us of the anaphylactic reaction of KS. Coronary artery spasm of type 1 KS was diagnosed based upon the findings of coronary computerized tomography. Eleven days after the first surgery, the patient underwent nephroureterectomy uneventfully by a change in antibiotics. Finally, cefazolin proved to be the trigger drug by the intradermal test.ConclusionWhen electrocardiogram changes suggesting ACS occur during general anesthesia, it is necessary to take KS into consideration as a differential diagnosis.
机译：摘要背景Kounis综合征（KS）被定义为伴有过敏性反应的急性冠状动脉综合征（ACS）的发生，在全麻下仅发生了几例报道。病例介绍一名69岁女性接受了经尿道切除术全身麻醉下的膀胱肿瘤。全身麻醉诱导后静脉注射头孢唑林。在手术过程中，我们怀疑心电图上的ST段突然下压导致ACS。红斑性皮疹的延迟发作使我们想起了KS的过敏反应。根据冠状动脉计算机断层扫描的发现，诊断为1型KS型冠状动脉痉挛。第一次手术后11天，患者因更换抗生素而顺利地进行了肾结直肠切除术。最后，经皮内试验证明头孢唑林是触发药物。结论当全身麻醉期间心电图改变提示ACS发生时，有必要将KS作为鉴别诊断。

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