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Neurogenesis and Alzheimer's Disease

机译:神经发生和阿尔茨海默氏病

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Alzheimer’s disease (AD) is a neurodegenerative disease, characterized in the brain by amyloid plaque deposits and neurofibrillary tangles. It is the most common form of dementia among older people. There is at present no cure for AD, and current treatments consist mainly in drug therapy. Potential therapies for AD involve gene and cellular therapy. The recent confirmation that neurogenesis occurs in the adult brain and neural stem cells (NSCs) reside in the adult central nervous system (CNS) provide new opportunities for cellular therapy in the CNS, particularly for AD, and to better understand brain physiopathology. Hence, researchers have aimed at characterizing neurogenesis in patients with AD. Studies show that neurogenesis is increased in these patients, and in animal models of AD. The effect of drugs used to treat AD on neurogenesis is currently being investigated, to identify whether neurogenesis contributes to their therapeutic activities.
机译:阿尔茨海默氏病(AD)是一种神经退行性疾病,其特征是大脑中的淀粉样斑块沉积和神经原纤维缠结。它是老年人中最常见的痴呆形式。目前尚无AD的治愈方法,目前的治疗主要包括药物治疗。 AD的潜在疗法涉及基因疗法和细胞疗法。最近证实神经发生发生在成年大脑中,而神经干细胞(NSCs)则存在于成年中枢神经系统(CNS)中,这为中枢神经系统(尤其是AD)中的细胞治疗提供了新的机会,并且可以更好地了解脑部生理病理。因此,研究人员旨在表征AD患者的神经发生。研究表明,在这些患者和AD动物模型中神经发生增加。目前正在研究用于治疗AD的药物对神经发生的作用,以鉴定神经发生是否有助于其治疗活性。

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