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首页> 外文期刊>Drug Target Insights >Effect of Ribavirin Alone or Combined with Silymarin on Carbon Tetrachloride Induced Hepatic Damage in Rats
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Effect of Ribavirin Alone or Combined with Silymarin on Carbon Tetrachloride Induced Hepatic Damage in Rats

机译：利巴韦林单独或联合水飞蓟素对四氯化碳致大鼠肝损伤的影响。

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The effect of the antiviral agent ribavirin given alone or in combination with silymarin on the development of liver injury induced in rats with carbon tetrachloride (CCl4; 2.8 ml/kg followed by 1.4 ml/kg after one week) was studied. Ribavirin at three dose levels (30, 60 or 90 mg/kg), silymarin (25 mg/kg) or combination of ribavirin (60 mg/kg) and silymarin (25 mg/kg) was administered once daily orally for 14 days, starting at time of administration of CCl4. The administration of ribavirin decreased the elevations in serum alanine aminotransferase (ALT) by 78.5, 82.1, 75.1%, aspartate aminotransferase (AST) 47.5, 37.4, 38.8%, and alkaline phosphatase (ALP) by 23.4, 16, 21.6%, respectively and also prevented the development of hepatic necrosis caused by CCl4. In comparison, the elevated serum ALT, AST and ALP levels decreased to 43.3%, 46%, and 37.5% of controls, respectively by silymarin. When silymarin was combined with ribavirin, the serum activities of AST and ALP were further decreased, indicating a benefi cial additive effect. Morphometric analysis indicated signifi cant reduction in the area of necrosis and fi brosis on ribavirin treatment and this was further reduced after the addition of silymarin. Metabolic pertuberations caused by CCl4 as refl ected in a decrease in intracellular protein content in hepatocytes were improved by ribavirin monotherapy and to higher extent by combined silymarin and ribavirin therapy. Proliferating cell nuclear antigen was reduced in nuclei of hepatocytes by ribavirin montherapy or the combination of ribavirin and silymarin compared with CCl4-control group. The study demonstrates that ribavirin treatment in the model of CCl4- induced liver injury results in less liver damage. Results also indicate that the combined application of ribavirin and silymarin is likely to be a useful additive in reducing liver injury.
机译：研究了单独或与水飞蓟素联合使用的抗病毒剂利巴韦林对四氯化碳（CCl4; 2.8 ml / kg，然后一周后1.4 ml / kg）诱导的大鼠肝损伤发展的影响。三种口服剂量的利巴韦林（30、60或90 mg / kg），水飞蓟素（25 mg / kg）或利巴韦林（60 mg / kg）和水飞蓟素（25 mg / kg）的组合每天口服一次，持续14天，从施用CCl4时开始。利巴韦林的施用分别使血清丙氨酸转氨酶（ALT）升高78.5％，82.1％，75.1％，天冬氨酸转氨酶（AST）47.5％，37.4％，38.8％和碱性磷酸酶（ALP）升高分别降低23.4％，16.21.6％和还可以防止由CCl4引起的肝坏死的发展。相比之下，水飞蓟素提高的血清ALT，AST和ALP水平分别降至对照组的43.3％，46％和37.5％。水飞蓟素与利巴韦林联用时，AST和ALP的血清活性进一步降低，表明具有有益的加和作用。形态分析表明，利巴韦林治疗后坏死和纤维化区域明显减少，加入水飞蓟素后进一步减少。利巴韦林单药治疗改善了肝细胞内细胞内蛋白质含量减少所反映的由CCl4引起的代谢渗透，而水飞蓟素和利巴韦林联合治疗则在更大程度上改善了代谢。利巴韦林单药治疗或利巴韦林和水飞蓟素联合治疗与CCl4对照组相比，肝细胞核中增殖细胞核抗原减少。该研究表明，利巴韦林在CCl4诱导的肝损伤模型中的治疗可减少肝损伤。结果还表明，利巴韦林和水飞蓟素的联合应用可能是减少肝损伤的有用添加剂。

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