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首页> 外文期刊>Drug Target Insights >Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility
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Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility

机译：黄体生成素受体在运动障碍患者和无运动障碍患者胃肠道中的表达

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摘要

Leuprolide is a gonadotropin-releasing hormone (GnRH) analog which has been shown to reduce symptoms in patients with irritable bowel syndrome (IBS) and chronic intestinal pseudo-obstruction (CIPO). The mechanism is not known, but one hypothesis is through down-modulation of luteinizing hormone (LH) secretion, a hormone whith antagonistic effect on gastrointestinal motility. However, presence of LH receptors in the gastrointestinal tract has never been described. The aim of this study was to find one possible way of action for leuprolide by examining the presence of the LH receptor, and if present, to see whether there was different expression in patients with or without dysmotility. Full-thickness biopsies from the bowel wall of patients with and without severe dysmotility were examined using immunohistochemistry staining. Biopsies showed expression of LH receptors on myenteric neurons and in glial cells, neutrophils, endothelial cells and mast cells. There was no difference in expression between patient groups.
机译：亮丙瑞林是一种促性腺激素释放激素（GnRH）类似物，已显示可减轻肠易激综合症（IBS）和慢性肠道假性阻塞（CIPO）患者的症状。该机制尚不清楚，但一个假设是通过降低黄体生成激素（LH）的分泌，这是一种对胃肠蠕动具有拮抗作用的激素。然而，从来没有描述过LH受体在胃肠道中的存在。这项研究的目的是通过检查LH受体的存在来找到亮丙瑞林的一种可能的作用方式，如果存在的话，以查看是否存在运动障碍的患者中是否存在不同的表达。使用免疫组织化学染色检查了有或没有严重运动障碍的患者肠壁的全层活检。活检显示肌间皮神经元以及神经胶质细胞，嗜中性粒细胞，内皮细胞和肥大细胞中LH受体的表达。患者组之间的表达没有差异。

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