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首页> 外文期刊>Japanese Journal of Pharmacology >Antagonistic Effect of N-(3-Aminopropyl)cyclohexylamine on Neurotrophic Action of Spermine in Primary Cultured Rat Hippocampal and Cerebellar Neurons
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Antagonistic Effect of N-(3-Aminopropyl)cyclohexylamine on Neurotrophic Action of Spermine in Primary Cultured Rat Hippocampal and Cerebellar Neurons

机译：N-（3-氨基丙基）环己胺对原代培养的大鼠海马和小脑神经元精胺神经营养作用的拮抗作用

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References(13) Cited-By(3) We previously found that spermine potently promotes the neuronal survival and regeneration of primary cultured brain neurons. N-(3-Aminopropyl)cyclohexylamine (APCHA) was originally developed as a spermine synthase inhibitor. To test if endogenous spermine biosynthesis contributes to neuronal survival and morphogenesis, we examined the effects of APCHA in primary cultured rat hippocampal and cerebellar neurons. APCHA at concentrations up to 10-6 M did not affect the neuronal survival, but significantly blocked the survival-promoting effect of spermine (10-8 M). APCHA also blocked the spermine-induced promotion of neurite regeneration following axotomy. Unlike APCHA, another cyclohexylamine derivative trans-4-methylcyclohexylamine did not affect the neurotrophic effect of spermine. These results suggest that in primary cultured brain neurons, APCHA works as a spermine antagonist rather than as a spermine synthesis inhibitor.
机译：参考文献（13）Cited-By（3）我们先前发现精胺能有效促进原代培养的脑神经元的神经元存活和再生。 N-（3-氨基丙基）环己胺（APCHA）最初是作为精胺合成酶抑制剂开发的。为了测试内源性精胺的生物合成是否有助于神经元的存活和形态发生，我们检查了APCHA在原代培养的大鼠海马和小脑神经元中的作用。浓度高达10-6 M的APCHA不会影响神经元存活，但会显着阻碍精胺（10-8 M）的存活促进作用。 APCHA还阻止了精胺诱导的轴突切开后神经突再生的促进。与APCHA不同，另一种环己胺衍生物反式-4-甲基环己胺不会影响精胺的神经营养作用。这些结果表明，在原代培养的脑神经元中，APCHA用作精胺拮抗剂而不是精胺合成抑制剂。

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