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Histological Evidence for Neuroprotective Action of Nebracetam on Ischemic Neuronal Injury in the Hippocampus of Stroke-Prone Spontaneously Hypertensive

机译:Nebracetam对中风自发性高血压海马缺血性神经元损伤的神经保护作用的组织学证据

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References(14) Cited-By(4) The protective effect of nebracetam on ischemic neuronal damage was histologically examined in the pyramidal cell layer of the hippocampal CAI subfield 7 days after operation using stroke-prone spontaneously hypertensive rats (SHRSP) subjected to 10-min bilateral carotid occlusion. Nebracetam (50 and 100 mg/kg), given orally 10 min after reperfusion, dose-dependently protected against ischemic delayed neuronal damage in the SHRSP with occlusion; however, the blood pressure remained unchanged following nebracetam administration. These findings further support the notion that nebracetam protects against ischemic delayed neuronal cell death in the hippocampus.
机译:参考文献(14)被引用的By(4)使用易发中风的自发性高血压大鼠(SHRSP),在接受手术的7天后,于术后7天在海马CAI亚区的锥体细胞层中组织检查了奈布西坦对缺血性神经元损伤的保护作用。分钟双侧颈动脉闭塞。再灌注后10 min口服内布西坦(50和100 mg / kg),剂量依赖性地保护SHRSP中具有闭塞作用的缺血性迟发性神经元损伤;但是,给予奈布西坦后,血压保持不变。这些发现进一步支持了奈布西坦可以防止海马缺血性神经元细胞死亡的观念。

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