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首页> 外文期刊>Japanese Journal of Pharmacology >Alteration of Bone Status with Ascorbic Acid Deficiency in ODS (Osteogenic Disorder Shionogi) Rats
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Alteration of Bone Status with Ascorbic Acid Deficiency in ODS (Osteogenic Disorder Shionogi) Rats

机译：ODS（骨源性疾病盐沼木）大鼠抗坏血酸缺乏症的骨状态改变

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References(16) Cited-By(14) Rats with hereditary defects in ascorbic acid (AsA) synthesis (ODS rats) subjected to AsA-deficiency for 3 weeks showed reductions of plasma alkaline phosphatase and dry and ash weights of the tibia, but no body weight alteration. In accordance with the chemical changes, bone loss and decrease of bone formation by AsA deficiency but not by malnutrition were observed in contact microradiographs of the tibia and by a tetracycline double labeling technique, respectively. The mechanical properties of femora measured by a three point-bending procedure were also altered by AsA deficiency for 3 weeks and showed decreases of 59% in toughness, 32% in strength, 32% in ductility and 22% in stiffness. The biomechanical changes by AsA deficiency were greater than the chemical changes in bone, indicating the usefulness of measuring mechanical properties as a sensitive method for the evaluation of the bone status. The second moment of the area of the femur was not changed by AsA deficiency. These results suggest that AsA deficiency in ODS rats causes marked bone loss and reduction in bone formation, which is accompanied by a greater reduction in biomechanics of the femur without causing macroarchitectural changes.
机译：参考文献（16）被引用的By（14）抗坏血酸（AsA）合成存在遗传缺陷的大鼠（ODS大鼠）进行AsA缺乏3周后，血浆碱性磷酸酶降低，胫骨干重和灰分降低，但没有体重改变。根据化学变化，分别在胫骨接触式X射线照相术和四环素双标记技术中观察到AsA缺乏而不是营养不良造成的骨丢失和骨形成减少。通过三点弯曲程序测量的股骨的机械性能也因AsA缺乏而改变了3周，其韧性降低了59％，强度降低了32％，延展性降低了32％，刚度降低了22％。 AsA缺乏引起的生物力学变化大于骨骼的化学变化，表明测量机械性质作为评估骨状态的敏感方法很有用。 AsA缺乏症未改变股骨区域的第二时刻。这些结果表明，ODS大鼠中AsA缺乏会导致明显的骨质流失和骨形成减少，同时伴有股骨生物力学的更大程度降低，而不会引起宏观结构改变。

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