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首页> 外文期刊>Jornal Brasileiro de Patologia e Medicina Laboratorial >Use of ischemia modified albumin for the diagnosis of myocardial infarction
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Use of ischemia modified albumin for the diagnosis of myocardial infarction

机译：缺血修饰白蛋白在诊断心肌梗死中的应用

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ABSTRACT Introduction: Literature reports addressing ischemia modified albumin (IMA) as a good marker for the early diagnosis of myocardial ischemia through albumin cobalt binding (ACB) test, that is before myocardial infarction (MI) occurs. Objective: To evaluate the IMA plasmatic levels in infarcted patients, in order to verify its potential as an early marker for early diagnosis of MI, investigate its correlation with existing cardiac biomarkers such as total creatine kinase (CK) and creatine kinase-MB fraction (CK-MB), as well as to assess the correlation between IMA and oxidative stress. Methods: The sample was divided into two groups according to serum troponin I (TnI) results; one group of infarcted patients (with MI) (TnI levels higher than 0.05 ng/ml), and the other group of non-infarcted patients (without MI) (TnI levels lower than 0.05 ng/ml). The results of total CK, CK-MB, thiobarbituric acid reactive substances (TBARS), and IMA were analyzed in both groups. Results: Regarding the existing cardiac markers, there was a significant increase of total CK and CK-MB levels in With MI group. In relation to the oxidative stress parameter, a significant increase was observed in with MI group compared to without MI group. However, IMA showed no significant difference between the groups; and also there was no significant correlation between IMA and the cardiac markers. There was no correlation between IMA and TBARS. Conclusion: Our results suggest that IMA cannot be used alone for the diagnosis of MI.
机译：摘要简介：文献报道将缺血修饰的白蛋白（IMA）作为通过心肌白蛋白钴结合（ACB）测试（即在心肌梗塞（MI）发生之前）早期诊断心肌缺血的良好标记。目的：评估梗死患者的IMA血浆水平，以验证其作为MI早期诊断的早期标志物的潜力，研究其与现有心脏生物标志物（如总肌酸激酶（CK）和肌酸激酶-MB分数）的相关性（ CK-MB），以及评估IMA和氧化应激之间的相关性。方法：根据血清肌钙蛋白I（TnI）结果分为两组。一组梗死患者（MI）（TnI水平高于0.05 ng / ml），另一组非梗死患者（无MI）（TnI水平低于0.05 ng / ml）。对两组的总CK，CK-MB，硫代巴比妥酸反应性物质（TBARS）和IMA的结果进行了分析。结果：就现有的心脏标志物而言，With MI组的总CK和CK-MB水平显着增加。关于氧化应激参数，与没有MI组相比，在MI组中观察到显着增加。但是，IMA显示两组之间无显着差异。而且IMA与心脏标志物之间也没有显着相关性。 IMA与TBARS之间没有关联。结论：我们的结果表明IMA不能单独用于MI的诊断。

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