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Atopic Dermatitis and the Atopic March: What Is New?

机译：特应性皮炎和特应性三月：新变化？

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Objective. In this paper the authors review the management of atopic dermatitis (AD) and the association between AD and allergic respiratory diseases. Data Sources. PubMed databases, researching articles in the last 15 years. Results. Studies about atopic march are cross-sectional population studies at different ages. They show that the most important predisposing factor for atopy is a decrease of the filaggrin's expression. Conclusions. The most modern theories seem to show that the most important factor which starts the atopic march is represented by an impaired epidermal barrier. It causes an increase in skin permeability to allergens that could induce sensitization even in the airways. The major predisposing factor is a primary inherited epithelial barrier defect resulting from filaggrin gene mutation, but other factors may play a role in this complex mechanism. Further studies are needed to focus on AD treatment and preventive strategies.
机译：目的。在本文中，作者回顾了特应性皮炎（AD）的管理以及AD与过敏性呼吸道疾病之间的关联。数据源。 PubMed数据库，研究过去15年中的文章。结果。关于特应性行军的研究是不同年龄的横断面人群研究。他们表明，特应性最重要的诱因是丝蛋白的表达降低。结论最现代的理论似乎表明，开始异位性进行的最重要因素是表皮屏障受损。它导致皮肤对过敏原的渗透性增加，甚至在呼吸道中也可能引起过敏。主要诱因是丝聚蛋白基因突变导致的原发性遗传性上皮屏障缺陷，但其他因素可能在这种复杂机制中起作用。需要进一步研究以集中于AD治疗和预防策略。

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