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首页> 外文期刊>Recent Patents on Inflammation & Allergy Drug Discovery >Atopic Dermatitis and Cytokines: The Immunoregulatory and Therapeutic Implications of Cytokines in Atopic Dermatitis - Part II: Negative Regulation and Cytokine Therapy in Atopic Dermatitis
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Atopic Dermatitis and Cytokines: The Immunoregulatory and Therapeutic Implications of Cytokines in Atopic Dermatitis - Part II: Negative Regulation and Cytokine Therapy in Atopic Dermatitis

机译：特应性皮炎和细胞因子：特应性皮炎中细胞因子的免疫调节和治疗意义-第二部分：特应性皮炎的负调节和细胞因子治疗

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摘要

Atopic dermatitis is an immunologic disease that results in allergic inflammations of the skin. Cytokines are involved in the negative regulation of immunopathogenesis of atopic dermatitis. Negative immune regulation is also achieved by immune cells in addition to cytokines which are subsequently regulated by a counter-regulatory mechanism. Allergen tolerance is an important aspect of the treatment of atopic dermatitis. Recently, the IL-27, IL-21, and IL-10 cytokines were found to be important components of the counter regulatory mechanism that terminates immune response, and protects the host from excessive immune responses. IL-10 and TGF-beta are well-known to be involved in the immune tolerance. IL-10 and IFN-y are promising cytokines with respect to the prevention of allergen sensitization and the induction of allergen-specific tolerance. In particular, IFN-gamma has unique tolerogenic effects with respect to pre-sensitized allergens, especially in atopic dermatitis. In this review, the role of cytokines in the immune tolerance and relevant patents are reviewed, and therapeutic strategies are presented based on the immunologic architecture of AD.
机译：特应性皮炎是一种免疫性疾病，可导致皮肤过敏性炎症。细胞因子参与特应性皮炎免疫病理的负调节。除细胞因子外，免疫细胞也可实现负免疫调节，而细胞因子随后可通过反调节机制进行调节。过敏原耐受性是特应性皮炎治疗的重要方面。最近，发现IL-27，IL-21和IL-10细胞因子是终止免疫反应并保护宿主免受过度免疫反应的反调节机制的重要组成部分。众所周知，IL-10和TGF-β参与免疫耐受。 IL-10和IFN-γ在预防变应原致敏和诱导变应原特异性耐受方面是有希望的细胞因子。特别地，IFN-γ对预致敏变应原具有独特的致癌作用，尤其是在特应性皮炎中。在这篇综述中，综述了细胞因子在免疫耐受中的作用和相关专利，并根据AD的免疫学结构提出了治疗策略。

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