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Rhinosinusitis and Aspirin-Exacerbated Respiratory Disease

机译:鼻鼻窦炎和阿司匹林加重呼吸道疾病

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Rhinosinusitis is a feature of aspirin-exacerbated respiratory disease (AERD), which in the initial phase is manifested as nasal congestion, mostly affecting females at the age of around 30 years on average. Subsequently, nasal inflammation progresses to chronic eosinophilic rhinosinusitis, asthma, nasal polyposis, and intolerance to aspirin and to other NSAIDs. While it has been long established that NSAIDs cause inhibition of cyclooxygenase-1 (COX-1), leading to excessive metabolism of arachidonic acid (AA) to cysteinyl-leukotrienes (cys-LTs), there is now evidence that both cytokines and staphylococcus superantigens amplify the inflammatory process exacerbating the disease. This paper gives a brief overview of the development of chronic rhinosinusitis (CRS) in sensitive patients, and we share our experience in the diagnosis and management of CRS in AERD.
机译:鼻-鼻窦炎是阿司匹林加重性呼吸道疾病(AERD)的特征,在最初阶段表现为鼻塞,主要影响平均年龄在30岁左右的女性。随后,鼻炎症发展为慢性嗜酸性鼻-鼻窦炎,哮喘,鼻息肉和对阿司匹林和其他非甾体抗炎药不耐受。长期以来,人们一直认为NSAIDs会抑制环氧合酶1(COX-1),导致花生四烯酸(AA)过度代谢为半胱氨酸-白三烯(cys-LTs),但现在有证据表明细胞因子和葡萄球菌超抗原加剧炎症过程,加剧疾病。本文简要概述了敏感患者的慢性鼻鼻窦炎(CRS)的发展,我们分享了在AERD中CRS的诊断和管理方面的经验。

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