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首页> 外文期刊>Journal of Allergy >Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The Pilot Study
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Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity: The Pilot Study

机译：有和没有阿司匹林超敏反应的哮喘患者在支气管阿司匹林激发后呼出类二十烷酸的初步研究

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Background. Special regulatory role of eicosanoids has been postulated in aspirin-induced asthma. Objective. To investigate effects of aspirin on exhaled breath condensate (EBC) levels of eicosanoids in patients with asthma. Methods. We determined EBC eicosanoid concentrations using gas chromatography/mass spectrometry (GC-MS) and high-performance liquid chromatography/mass spectrometry (HPLC-MS2) or both. Determinations were performed at baseline and following bronchial aspirin challenge, in two well-defined phenotypes of asthma aspirin-sensitive and aspirin-tolerant patients. Results. Aspirin precipitated bronchial reactions in all aspirin-sensitive, but in none of aspirin-tolerant patients (ATAs). At baseline, eicosanoids profile did not differ between both asthma groups except for lipoxygenation products 5- and 15-hydroxyeicosatetraenoic acid (5-, 15-HETE) which were higher in aspirin-induced asthma (AIA) than inaspirin-tolerant subjects. Following aspirin challenge the total levels of cysteinyl-leukotrienes (cys-LTs) remained unchanged in both groups. The dose of aspirin had an effect on magnitude of the response of the exhaled cys-LTs and prostanoids levels only in AIA subjects. Conclusion. The high baseline eicosanoid profiling of lipoxygenation products 5- and 15-HETE in EBC makes it possible to detect alterations in aspirin-sensitive asthma. Cysteinyl-leukotrienes, and eoxins levels in EBC after bronchial aspirin administration in stable asthma patients cannot be used as a reliable diagnostic index for aspirin hypersensitivity.
机译：背景。类花生酸在阿司匹林诱发的哮喘中具有特殊的调节作用。目的。研究阿司匹林对哮喘患者类二十烷酸呼出气冷凝物（EBC）水平的影响。方法。我们使用气相色谱/质谱（GC-MS）和高效液相色谱/质谱（HPLC-MS2）或两者测定EBC类花生酸的浓度。在基线和支气管阿司匹林激发后，对哮喘阿司匹林敏感和阿司匹林耐受的两种明确表型进行了测定。结果。阿司匹林在所有对​​阿司匹林敏感的患者中引起支气管反应，但没有阿司匹林耐受的患者（ATA）。在基线时，两组之间的类花生酸分布没有差异，除了脂氧合产物5-和15-羟基二十碳四烯酸（5-，15-HETE）在阿司匹林诱发的哮喘（AIA）中高于耐阿司匹林的受试者。阿司匹林激发后，两组中半胱氨酰-白三烯（cys-LTs）的总水平保持不变。仅在AIA受试者中，阿司匹林的剂量对呼出的cys-LTs和类前列腺素水平的反应幅度有影响。结论。 EBC中脂氧合产物5-和15-HETE的高基线类花生酸谱分析使检测阿司匹林敏感性哮喘的变化成为可能。在稳定的哮喘患者中，支气管阿司匹林给药后，EBC中的半胱氨酸-白三烯和Eoxins水平不能用作阿司匹林超敏反应的可靠诊断指标。

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