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首页> 外文期刊>Journal of Allergy >Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control
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Serum Leptin and Adiponectin Levels in Obese and Nonobese Asthmatic School Children in relation to Asthma Control

机译：肥胖和非肥胖哮喘儿童的血清瘦素和脂联素水平与哮喘控制相关

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摘要

There is growing evidence of a positive correlation between asthma and obesity in children and adults. Leptin and adiponectin regulate several metabolic and inflammatory functions. This study aims to evaluate serum leptin and adiponectin concentrations in asthmatic school children to investigate their association with obesity and the degree of asthma control. Obese asthmatic (OA) and nonobese asthmatic (NOA) children, aged 7 to 14, were randomly enrolled in this prospective study. Data on demographic, anthropometric, serum lipids, and spirometric measures and allergy status were collected and analyzed. Serum leptin was significantly higher ( versus ; ) and adiponectin levels were lower ( versus ; ) in OA compared to NOA children. The uncontrolled group had higher leptin and lower adiponectin levels compared to well and partially controlled asthma. BMI was positively correlated with leptin (; ) and negatively with adiponectin (; ). Mean BMI and leptin levels were observed to be higher in girls compared to boys. Stepwise multiple linear regression analysis showed that higher BMI and female gender had significant effect on serum leptin levels. Among asthmatic children higher serum leptin and lower adiponectin levels were significantly associated with obesity and showed no significant association with degree of asthma controls.
机译：越来越多的证据表明，儿童和成人的哮喘与肥胖之间存在正相关。瘦素和脂联素调节几种代谢和炎症功能。本研究旨在评估哮喘小学生的血清瘦素和脂联素浓度，以调查他们与肥胖症和哮喘控制程度的关系。这项前瞻性研究随机纳入了7至14岁的肥胖哮喘（OA）和非肥胖哮喘（NOA）儿童。收集并分析了有关人口统计学，人体测量学，血脂，肺活量测量和过敏状况的数据。与NOA儿童相比，OA中的血清瘦素显着较高（与;相比），而脂联素水平则较低（与;相比）。与完全控制和部分控制的哮喘相比，非控制组的瘦素水平和脂联素水平较低。 BMI与瘦素（;）正相关，与脂联素（;）负相关。观察到女孩的平均BMI和瘦素水平高于男孩。逐步多元线性回归分析表明，较高的BMI和女性对血清瘦素水平有显着影响。在哮喘儿童中，较高的血清瘦素和较低的脂联素水平与肥胖显着相关，与哮喘控制程度无显着相关性。

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