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首页> 外文期刊>Journal of Behavioral and Brain Science >Alterations in Caspase-3 in Juvenile Rats Treated Neonatally with Domoic Acid
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Alterations in Caspase-3 in Juvenile Rats Treated Neonatally with Domoic Acid

机译：海藻酸对新生大鼠新生大鼠半胱氨酸天冬氨酸蛋白酶3的影响

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The clinical presentation of schizophrenia involves a variety of symptoms, which in many cases include hallucinations and delusions. Experimentally revealed alterations in both pre-pulse inhibition (PPI) and latent inhibition (LI) are also apparent in individuals afflicted with this disorder. Many have speculated that altered synaptic connections are, in part, responsible for this subset of behavioral abnormalities. We have previously reported that neonatal chronic low-dose injections of domoic acid (DOM) produce adult rats with deficits in PPI and LI. The current study was conducted to determine whether this toxin-treatment would alter the degree of apoptosis occurring in the developing brain. Results revealed significant decreases in caspase-3 within the right prelimbic cortex (PrL) in both male and female DOM-treated rats suggesting that even modest alterations in glutamate (Glu) signaling during critical periods of central nervous system (CNS) maturation will modify ontogenetic processes in the prefrontal cortex (PFC) of the juvenile rat.
机译：精神分裂症的临床表现涉及多种症状，在许多情况下包括幻觉和妄想。实验显示，在患有这种疾病的个体中，前脉冲抑制（PPI）和潜伏抑制（LI）的变化也很明显。许多人推测，突触连接的改变部分是造成这种行为异常的原因。我们以前曾报道过，新生儿慢性低剂量多莫酸（DOM）注射会产生成年大鼠PPI和LI不足。进行当前的研究以确定这种毒素治疗是否会改变发育中的大脑中发生的细胞凋亡程度。结果显示，雄性和雌性DOM处理的大鼠右前肢皮层（PrL）内caspase-3的显着降低，表明即使在中枢神经系统（CNS）成熟的关键时期谷氨酸（Glu）信号的适度改变也会改变个体发育幼鼠的前额叶皮层（PFC）中的过程。

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