...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Behavioral and Brain Science >Dysregulation within the Prefronto-Parietal Background-Monitoring Network in Schizophrenia
【24h】

Dysregulation within the Prefronto-Parietal Background-Monitoring Network in Schizophrenia

机译：精神分裂症前额顶壁背景监测网络内的调节异常

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Schizophrenia patients have difficulties in focusing their attention, when distracting information must be ignored. Although it is adaptive in some situations to monitor the background for potentially relevant changes to a certain degree, voluntary attentional processes seem to be more severely disrupted by distracting information in schizophrenia patients compared to healthy controls. Reorienting processes associated with the detection of potentially relevant information outside the current focus of attention have previously shown to activate a bilateral prefronto-parietal network. The aim of the current study was to investigate whether this network is dysregulated in schizophrenia patients using fMRI during the performance in a combined oddball-incongruence task, in which relevant processing must be shielded from distracting irrelevant salient or conflicting information. During the occurrence of both oddballs and incongruence patients exhibited an increased activation of the intraparietal cortex—a saliency sensitive part of the prefronto-parietal network associated with background-monitoring. As this hyperactivation was accompanied by an increased activation in the dopaminergic midbrain, the results of our study link the finding of a hyperactive salience sensitive cortical region to the finding of the hyperdopaminergic state in schizophrenia, supporting the predominant view of psychosis as a state of aberrant salience.
机译：当必须分散注意力的信息时，精神分裂症患者很难集中注意力。尽管在某些情况下可以在一定程度上监视背景的潜在相关变化，但与健康对照组相比，精神分裂症患者的注意力分散似乎会严重干扰自愿注意力过程。先前已经显示出与在当前关注的焦点之外的潜在相关信息的检测相关的重新定向过程激活了双边前额顶网络。本研究的目的是调查在合并的奇异球不协调任务中使用fMRI在精神分裂症患者中该网络是否失调，其中必须屏蔽相关处理，以免分散无关紧要的信息或冲突的信息。在发生奇数球和不一致的情况下，患者的顶内皮层激活增强-前额顶壁网络的显着性敏感部分与背景监测相关。由于这种过度活化伴随着多巴胺能中脑的活化增加，因此我们的研究结果将精神分裂症的高活跃性显着敏感皮层区的发现与高多巴胺能状态的发现联系起来，从而支持了将精神病视为异常状态的主要观点。显着性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号