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首页> 外文期刊>Journal of atherosclerosis and thrombosis. >Tenascin-C May Be a Predictor of Acute Pulmonary Thromboembolism
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Tenascin-C May Be a Predictor of Acute Pulmonary Thromboembolism

机译:Tenascin-C可能是急性肺血栓栓塞的预测因子

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Aim: Numerous studies have shown an increase in NT-pro BNP, troponin I and D-dimer levels with right ventricular dysfunction on echocardiography in patients with acute pulmonary thromboembolism (PTE). We found no data about the relation between tenascin-C and acute PTE in the litera-ture. The aim of this study was to evaluate tenascin-C levels in acute PTE and correlate them with NT-pro BNP, troponin I and D-dimer. Method: Thirty-four patients who have massive or submassive PTE on spiral thorax CT (PTE group) and twenty healthy volunteers (non-PTE group) were evaluated. In all patients, right ventricular functions were obtained on transthoracic echocardiography and plasma tenascin-C, NT-pro BNP, troponin I, and D-dimer levels were measured. Results: The left ventricular systolic diameter, left ventricular diastolic diameter and left ventricular ejection fraction were similar in the two groups. The right heart chamber sizes and main pulmonary artery diameter were significantly larger in the PTE group and systolic pulmonary artery pressures were also significantly higher in this group. Tenascin-C, NT-pro BNP, and D-dimer levels were also significantly higher in the PTE group than in the non-PTE group ( p < 0.001). The troponin I levels did not differ between the two groups ( p =0.4). Tenascin-C was found to be highly correlated with sPAP and NT-pro BNP and correlated with D-dimer; however, troponin I was not correlated with tenascin-C. Conclusion: This study demonstrates that tenascin-C may be an indicator of acute PTE.
机译:目的:许多研究表明,急性肺血栓栓塞症(PTE)患者在超声心动图上发现NT-pro BNP,肌钙蛋白I和D-二聚体水平升高,伴右心功能不全。我们在文献中没有发现有关腱生蛋白-C和急性PTE之间关系的数据。这项研究的目的是评估急性PTE中的腱生蛋白C水平并将其与NT-pro BNP,肌钙蛋白I和D-二聚体相关联。方法:评估了34例螺旋胸部CT上有大块或亚块型PTE的患者(PTE组)和20名健康志愿者(非PTE组)。在所有患者中,经胸超声心动图检查均获得了右心室功能,并测量了血浆腱生蛋白-C,NT-pro BNP,肌钙蛋白I和D-二聚体水平。结果:两组左心室收缩直径,左心室舒张直径和左心室射血分数相似。 PTE组的右心室大小和主要肺动脉直径明显更大,而该组的收缩期肺动脉压力也明显更高。 PTE组中的腱生蛋白-C,NT-pro BNP和D-二聚体水平也显着高于非PTE组(p <0.001)。两组之间的肌钙蛋白I水平无差异(p = 0.4)。发现腱生蛋白C与sPAP和NT-pro BNP高度相关,并与D-二聚体相关。然而,肌钙蛋白I与肌腱蛋白-C不相关。结论:这项研究表明,腱生蛋白-C可能是急性PTE的指标。

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