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首页> 外文期刊>Journal of Behavioral and Brain Science >The Ventral Ascending Noradrenergic Bundles Are Involved in the Stress Response to Immobilization in Rats
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The Ventral Ascending Noradrenergic Bundles Are Involved in the Stress Response to Immobilization in Rats

机译：腹升升去甲肾上腺素束涉及对大鼠固定化的应激反应。

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Stressful stimuli induced by immobilization are perceived as acute stress in rats. This acute stress activates corticotropin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN), resulting in stimulation of the hypothalamic-pituitary-adrenal (HPA) axis. The ventral ascending noradrenergic bundles (V-NAB) from the brainstem innervate the PVN. To investigate the relationship between the response of the HPA axis and the V-NAB, we examined changes in plasma corticosterone, the final output of the HPA axis, and extracellular noradrenaline (NA) in the PVN following immobilization stress in rats that received bilateral 6-hydroxydopamine (6-OHDA) lesions of the V-NAB. 6-OHDA microinjection into the V-NAB reduced the magnitude of the responses of plasma corticosterone and extracellular NA in the PVN following immobilization stress. Our results suggest that V-NAB innervation of the PVN is involved in immobilization stress-induced activation of the HPA axis.
机译：固定引起的应激刺激被认为是大鼠的急性应激。这种急性应激会激活下丘脑室旁核（PVN）中的促肾上腺皮质激素释放激素（CRH）神经元，从而刺激下丘脑-垂体-肾上腺（HPA）轴。来自脑干的腹侧上升去甲肾上腺素束（V-NAB）支配PVN。为了研究HPA轴和V-NAB的反应之间的关系，我们研究了固定性应激后接受双侧大鼠6的血浆皮质酮，HPA轴的最终输出以及PVN在PVN中的变化。 V-NAB的-羟基多巴胺（6-OHDA）损伤。 V-NAB的6-OHDA显微注射降低了固定应力后PVN中血浆皮质酮和细胞外NA的反应幅度。我们的结果表明，PVN的V-NAB神经支配参与了固定应力诱导的HPA轴的激活。

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