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首页> 外文期刊>Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal >Effects of atomoxetine on attention and impulsivity in the five-choice serial reaction time task in rats with lesions of dorsal noradrenergic ascending bundle
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Effects of atomoxetine on attention and impulsivity in the five-choice serial reaction time task in rats with lesions of dorsal noradrenergic ascending bundle

机译：阿莫西汀对背肾上腺素升束性损伤大鼠五项选择反应时间任务中注意力和冲动的影响

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Atomoxetine, a noradrenaline reuptake inhibitor (NRI), which is a non-stimulating medicine that is used for the treatment of patients with attention deficit hyperactivity disorder (ADHD), has been found to be effective in reducing behavioral impulsivity in rodents, but its efficacy in a dorsal noradrenergic ascending bundle (DNAB)-lesioned condition has not been examined. The present study aimed to investigate the effects of DNAB lesions on attention and impulsive control in the five-choice serial reaction time task (5-CSRTT) in rats treated with atomoxetine. The drug-induced changes in noradrenaline efflux in the medial prefrontal cortex were also measured. 5-CSRTT-trained rats were included in one of the following groups: N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)/Atomoxetine, Sham/Atomoxetine, DSP-4/Saline, or Sham/Saline. Acute atomoxetine (0.3 mg/kg) was administered 14 days after the DSP-4 regime. The behavioral testing included manipulations of the inter-trial interval (ITI), stimulation duration and food satiety. In vivo microdialysis of the noradrenaline efflux in the medial prefrontal cortex and the expression of the noradrenaline transporter (NAT) in the DNAB areas were examined. Atomoxetine reduced impulsivity and perseveration in the long-ITI condition with no effects on any other variables. This phenomenon was not influenced by DSP-4 pre-treatment. The DNAB-lesioned rats had lower noradrenaline efflux in the medial prefrontal cortex. DSP-4 caused no change in NAT expression in the DNAB areas. These findings suggested that noradrenaline reuptake may not be exclusively responsible for the atomoxetine effects in adjusting impulsivity. The role of DNAB should also be considered, particularly in conditions requiring greater behavioral inhibition. (C) 2014 Elsevier Inc. All rights reserved.
机译：已经发现去甲肾上腺素去甲肾上腺素再摄取抑制剂（NRI）是一种非刺激性药物，用于治疗注意力不足过动症（ADHD）患者，可有效降低啮齿动物的行为冲动，但其功效尚未检查过背肾上腺素上升束（DNAB）病变的情况。本研究旨在研究在用阿托西汀治疗的大鼠的五选择序列反应时间任务（5-CSRTT）中DNAB损伤对注意力和冲动控制的影响。还测量了药物诱导的前额叶内侧皮质中去甲肾上腺素外排的变化。受5-CSRTT训练的大鼠包括在以下一组中：N-（2-氯乙基）-N-乙基-2-溴苄胺（DSP-4）/阿托莫西汀，深水/阿托莫西汀，DSP-4 /盐水或深水/盐水。在DSP-4方案治疗14天后给予急性阿托西汀（0.3 mg / kg）。行为测试包括试验间隔（ITI），刺激持续时间和食物饱腹感的操纵。检查了内侧前额叶皮层中去甲肾上腺素外排的体内微渗析以及DNAB区域中去甲肾上腺素转运蛋白（NAT）的表达。在长期ITI条件下，阿托莫西汀可降低冲动性和持久性，而对其他任何变量均无影响。此现象不受DSP-4预处理的影响。 DNAB损伤的大鼠前额叶内侧皮质的去甲肾上腺素外排较低。 DSP-4不会引起DNAB区域NAT表达的变化。这些发现表明去甲肾上腺素的再摄取可能不是阿莫西汀调节冲动的唯一原因。还应考虑DNAB的作用，特别是在需要更大行为抑制的条件下。 （C）2014 Elsevier Inc.保留所有权利。

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