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首页> 外文期刊>Journal of Behavioral and Brain Science >Xylocarpin H, a Limonoid of Xylocarpus granatum, Produces Antidepressant-Like Activities in Mice
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Xylocarpin H, a Limonoid of Xylocarpus granatum, Produces Antidepressant-Like Activities in Mice

机译：木糖苷H，木糖荚果的柠檬苦素，在小鼠中产生抗抑郁样活性

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Major depression is a common psychiatric disorder worldwide that imposes a substantial health burden on society. Currently available antidepressants do not meet the clinical needs. Here, we report that Xylocarpin H, a limonoid of Xylocarpus granatum, has antidepressant-like effects in mouse forced swimming and tail suspension tests, two validated models of depression. 7-day oral administration of Xylocarpin H resulted in dose-dependent decreases immobility duration within the dose range of 15 - 50 mg/kg. Xylocarpin H dose-dependently increases the time spent in the central zone at doses of 5 - 50 mg/kg in locomotion activity test. In addition, 7-day treatment Xylocarpus H at 15 and 50 mg/kg doses significantly decreases levels of serum corticosterone and adrenocorticotropic hormone (ACTH) following the acute stress of forced swimming test. Furthermore, these effective doses of Xylocarpin H do not affect locomotor activity and levels of serum corticosterone and ACTH in the absence of stress. In summary, the present study, for the first time, demonstrates that Xylocarpin H exerts antidepressant-like effects in mouse behavioral models of depression, likely by inhibiting HPA axis systems. These data provide primarily basis for developing Xylocarpin H as a novel antidepressant candidate for the treatment of depression and stress related disorders.
机译：严重抑郁症是世界范围内的一种常见精神病，对社会构成了沉重的健康负担。当前可用的抗抑郁药不能满足临床需求。在这里，我们报道了木香树的柠檬黄素类Xylocarpin H在小鼠强迫游泳和尾巴悬吊试验中具有抗抑郁样作用，这是两个经过验证的抑郁模型。木犀草素H的7天口服给药在15-50 mg / kg的剂量范围内导致剂量依赖性的固定持续时间减少。木犀草素H在运动活性试验中剂量依赖性地增加了以5-50 mg / kg的剂量在中部区域所花费的时间。另外，在强迫游泳试验的急性应激下，以15和50 mg / kg剂量进行7天的木果H的治疗显着降低了血清皮质酮和促肾上腺皮质激素（ACTH）的水平。此外，在没有压力的情况下，这些有效剂量的木糖甙H不会影响运动活性以及血清皮质酮和ACTH的水平。综上所述，本研究首次证明了木犀草蛋白酶H可能通过抑制HPA轴系统在抑郁症的小鼠行为模型中发挥了抗抑郁样作用。这些数据主要为开发木黄素H作为治疗抑郁症和压力相关疾病的新型抗抑郁药候选药物提供了基础。

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