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首页> 外文期刊>Journal of Behavioral and Brain Science >Administration of Zinc with Paroxetine Improved the Forced Swim Test Behavioral Pattern of Treated Mice in Acute and Sub-Acute Study
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Administration of Zinc with Paroxetine Improved the Forced Swim Test Behavioral Pattern of Treated Mice in Acute and Sub-Acute Study

机译：帕罗西汀与锌合用可改善治疗小鼠在急性和亚急性研究中的强迫游泳试验行为模式

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Despite progressive improvement in treating major depressive disorder (MDD), it remains mostly unresponsive to one antidepressant medication. Zinc is a brain highly abundant trace metal, a brain derived neurotrophic factor (BDNF) inducer, a modulator of synaptic plasticity and potent suppressor of the NMDA receptors. We proposed that co-administration of zinc with the antide-pressants may represent a valuable regimen to improve the efficacy of these drugs. This work has been implemented to evaluate the behavioral changes of acute and sub-acute co-administration of zinc with Paroxtine in mice. Methods: The animals were injected intra-peritoneal with either Paroxtine (20 mg/kg) which was a selective serotonin reuptake inhibitor (SSRI), zinc sulfate (30 mg/kg) or Paroxtine in combination with zinc for one day and one week (once daily). The pattern of the animal behavior was assessed in the forced swim test (FST). Results and Discussion: The behavioral patterns of the animals in the FST include immobility, swimming and climbing. Successful antidepressant should decrease the immobility time with either increase in swimming and/or climbing behavior based on the drug pharmacological activity. Our results revealed a significant decrease of immobility and increase of swimming behavior indicating serotonin-dependent pharmacological activity of Paroxtine or zinc alone as well as in the animals treated with zinc in combination with Paroxtine. There was no significant difference in the animals’ behavior between acute and sub-acute treatment with zinc or even upon its addition to paroxetine. Our data support the concept that co-administration of zinc may provide further antidepressant activity. Zinc may offer additional clinical value particularly in geriatric patients or other populations where zinc level has shown dramatic decrease.
机译：尽管在治疗重性抑郁症（MDD）方面取得了进步，但它对一种抗抑郁药仍然无反应。锌是大脑中高度丰富的微量金属，大脑衍生的神经营养因子（BDNF）诱导剂，突触可塑性的调节剂和NMDA受体的有效抑制剂。我们建议将锌与抗抑郁药合用可能是提高这些药物疗效的一种有价值的方案。这项工作已被实施以评估小鼠急性和亚急性锌与帕罗西汀共同给药的行为变化。方法：给动物腹膜内注射选择性羟色胺再摄取抑制剂（SSRI）的帕罗西汀（20 mg / kg），硫酸锌（30 mg / kg）或帕罗西汀与锌联用，分别在一天和一周内（每天一次）。在强迫游泳试验（FST）中评估动物行为模式。结果与讨论：FST中动物的行为方式包括不动，游泳和爬山。成功的抗抑郁药应基于药物药理活性而随着游泳和/或攀爬行为的增加而减少固定时间。我们的结果表明，固定性明显降低，游泳行为增加，这表明帕罗汀或锌单独以及与锌联合帕罗汀治疗的动物具有血清素依赖性药理活性。在锌的急性和亚急性治疗甚至加入帕罗西汀后，动物的行为无明显差异。我们的数据支持锌共同给药可能提供进一步抗抑郁活性的概念。锌可能会提供额外的临床价值，尤其是对于老年患者或其他锌水平显着下降的人群。

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