首页> 外文期刊>Journal of Behavioral and Brain Science >The Selective Serotonin Reuptake Inhibitor-Sertraline Diminishes Conspecific Aggression in Male Fighting Betta splendens Fish
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The Selective Serotonin Reuptake Inhibitor-Sertraline Diminishes Conspecific Aggression in Male Fighting Betta splendens Fish

机译:选择性5-羟色胺再摄取抑制剂-舍曲林减少雄性斗鱼B鱼的同种异体攻击。

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In conspecific type of aggression the modulation of 5-hydroxytryptamine (5-HT) plays a main role. A decrease of 5-HT in the brain intensifies this type of aggression and in contrast, the increase of 5-HT reduces it. The aim of this study was to examine the effects of different concentrations of sertraline HCl on aggressive behavior of Betta splendens male fish. It was concluded that sertraline added to aquarium water in the dose of 0.4, 4.0 and/or 100.0 μg·L-1 BW during 14 days of exposition increased synaptic levels of 5-HT which in turn resulted in reduction of specific aggressive behavior in the environmental concentrations (0.4 μg) and then times higher. Sertraline caused a periodic, and sometimes even total weakening of the male-male type fight, which was a standard trial applied in ethological research on the Siamese fighting fish. In the current study, the most effective one is proved to be the dose of 4.0 μg·L-1 BW (parallel to earlier investigated fluoxetine in the same dose).
机译:在特定类型的侵略中,调节5-羟色胺(5-HT)起主要作用。大脑中5-HT的降低会加剧这种侵略性,相反,5-HT的升高会降低这种侵略性。这项研究的目的是研究不同浓度的盐酸舍曲林盐酸盐对len鱼雄鱼攻击行为的影响。结论是:在暴露的14天中,以0.4、4.0和/或100.0μg·L-1 BW的剂量向鱼缸水中添加舍曲林会增加5-HT的突触水平,进而降低特定的攻击行为。环境浓度(0.4μg),然后高出几倍。舍曲林引起了雄性-雄性斗殴的周期性甚至有时是完全减弱,这是在暹罗斗鱼的行为学研究中应用的标准试验。在当前的研究中,最有效的方法被证明是4.0μg·L-1 BW的剂量(与之前研究的相同剂量的氟西汀平行)。

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