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首页> 外文期刊>Journal of Behavioral and Brain Science >Dyscirculatory Angiopathy of Alzheimer's Type
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Dyscirculatory Angiopathy of Alzheimer's Type

机译：阿尔茨海默氏病型循环障碍性血管病

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Purpose: We assess the significance of dyscirculatory angiopathy of Alzheimer’s type (DAAT) in identify- ing the predisposition to the development and diagnosis of Alzheimer’s disease (AD) different stages. Meth- ods: 108 patients took part in the research:1) 49 aged 34-79 suffering from AD or running an increased risk of its development (those not diagnosed with AD but having growing memory disorders without any mani- festations of dementia or specific cognitive impairments, and having 2 or more immediate relatives with AD) - Test Group; 2) 59 aged 28-78 suffering from different types of brain lesions accompanied by dementia but not suffering from AD or corresponding to their age norm - Control Group. All the patients underwent MRI, CT with subsequent calculation of the temporal lobes atrophy degree, brain scintigraphy (SG), rheoencepha- lography (REG), and MUGA. Results: Characteristic features of patients with an increased risk of AD as well as at its various stages are: 1) Temporal lobes and hippocampus atrophy ranging from 4% among those with an increased risk of AD to 62% among those at its advanced stages; 2) DAAT manifestations: reduction of the capillary bed in the temporal and frontoparietal regions with the development of multiple arterioven- ous shunts of the same localization and correspondent early venous discharge accompanied by venous stasis on the border of the frontal and parietal region; 3) DAAT phenomena equally develop both among those with an increased risk of developing AD and those at various AD stages. Similar changes are not observed among Control Group patients with other brain lesions, regardless of the severity of dementia, as well as among practically healthy people of the corresponding age group. Conclusion: Timely identification of the above- mentioned changes can reveal a predisposition to AD development long before its initial manifestations, and it allows differentiating AD from other diseases attended by dementia. In both cases, timely diagnosis allows beginning timely treatment and thus achieving more stable results.
机译：目的：我们评估阿尔茨海默氏病类型的循环障碍性血管病（DAAT）在确定易感性阿尔茨海默氏病（AD）不同阶段的发展和诊断中的意义。方法：108名患者参加了该研究：1）49岁的34-79岁患有AD或罹患AD的风险增加（那些未被诊断出患有AD但患有记忆障碍且没有任何痴呆或特定表现的人认知障碍，并且有2个或更多直系亲属（AD）-测试组; 2）59岁的28-78岁患有不同类型的脑部病变并伴有痴呆症，但未患有AD或未符合其年龄标准的人-对照组。所有患者均接受MRI，CT检查，随后计算颞叶萎缩程度，脑闪烁显像（SG），流变描记法（REG）和MUGA。结果：AD风险增加以及处于不同阶段的患者的特征如下：1）颞叶和海马萎缩的范围从AD风险增加的4％到晚期的62％; 2）DAAT表现：颞叶和绝经前区域毛细血管床减少，同时出现多个相同位置的动静脉分流，相应的早期静脉排出伴随额叶和顶叶区域边界处的静脉淤滞; 3）DAAT现象在罹患AD的风险增加的人和处于AD各个阶段的人中均会发展。不论痴呆症的严重程度如何，在具有其他脑部病变的对照组患者以及相应年龄组的实际健康人群中均未观察到类似的变化。结论：及时发现上述变化可早于AD的发展显示出AD易感性，并且可以将AD与痴呆伴有的其他疾病区分开。在这两种情况下，及时诊断都可以开始及时进行治疗，从而获得更稳定的结果。

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