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首页> 外文期刊>Journal of Behavioral and Brain Science >Effect of Ethanol Deprivation and Re-Exposure on the Ethanol Drinking Behaviour of the High-Alcohol-Drinker (UChB) Rats
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Effect of Ethanol Deprivation and Re-Exposure on the Ethanol Drinking Behaviour of the High-Alcohol-Drinker (UChB) Rats

机译：乙醇剥夺和再暴露对高酒精饮料（UChB）大鼠乙醇饮用行为的影响

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Alcohol addiction constitutes a major health problem in the general population, it is a complex pathology characterized by the development of tolerance, physical dependence and compulsive ethanol-seeking behaviour that often manifests as a chronic relapsing syndrome. 0ne of the major concerns in the treatment of alcohol-dependent patients is the prevention of relapse during periods of abstinence. The alcohol deprivation effect (ADE) is defined as a temporary increase in the voluntary intake of ethanol when it is reinstated after a period of alcohol deprivation and has been used as an animal model of relapse-like drinking. ADE can be used to evaluate the efficacy of possible pharmacological agents to prevent relapse drinking. The current study was undertaken to examine whether the high-alcohol-drinker UChB rats would display an ADE. Rats were given either continuous or periodic concurrent access to 10, 20% (vol/vol) of ethanol across deprivation cycles. UChB rats consuming ethanol voluntarily for two months, exhibit a robust ADE after a single deprivation period of two weeks. The increased alcohol intake during the early days of re-exposure, following a withdrawal phase, is attributed to a shift in preference towards the higher concentration of ethanol that might reflect an increase in craving for alcohol. Since an ADE is also observed in UChB rats, make this line of rats selectively bred for their high voluntary ethanol consumption, a useful model for study the efficacy of pharmacological agents for the treatment of relapse of alcohol consumption.
机译：酒精成瘾是普通人群中的主要健康问题，它是一种复杂的病理，其特征是耐受性，身体依赖性和强迫性饮酒行为的发展，通常表现为慢性复发综合征。酒精依赖患者治疗的主要关注点之一是在戒酒期间预防复发。酒精剥夺效应（ADE）的定义是，在一段时间的酒精剥夺后恢复酒精摄入后，自愿摄入的乙醇会暂时增加，并已用作复发性饮酒的动物模型。 ADE可用于评估可能的药理剂防止复发饮酒的功效。目前的研究是为了研究高酒精饮料的UChB大鼠是否会显示ADE。在剥夺周期中，连续或定期向大鼠提供10％，20％（体积/体积）的乙醇。自愿饮用乙醇的UChB大鼠在两个星期的单次剥夺期后表现出强大的ADE。在戒断阶段后的再暴露初期，酒精摄入量的增加归因于偏向高浓度乙醇的偏爱，这可能反映出对酒精的渴望增加。由于在UChB大鼠中也观察到ADE，因此使该系大鼠有选择地繁殖以提高其自愿性乙醇的摄入量，这是研究药理剂治疗酒精消耗复发的有用模型。

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